Asset Details
Do you wish to reserve the book?
The Role of Mucosal Immunity in Pertussis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Role of Mucosal Immunity in Pertussis
Do you wish to request the book?
The Role of Mucosal Immunity in Pertussis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Role of Mucosal Immunity in Pertussis
2019
Overview
Pertussis or whooping cough, mainly caused by
, is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. Vaccines against this disease are widely available since the 1950s. Despite high global vaccination coverage, the disease is not under control in any country, and its incidence is even increasing in several parts of the world. Epidemiological and experimental evidence has shown that the vaccines fail to prevent
infection and transmission, although they are very effective in preventing disease. Given the high infection rate of
, effective control of the disease likely requires prevention of infection and transmission in addition to protection against disease. With rare exceptions
infections are restricted to the airways and do not usually disseminate beyond the respiratory epithelium. Therefore, protection at the level of the respiratory mucosa may be helpful for an improved control of pertussis. Yet, compared to systemic responses, mucosal immune responses have attracted relatively little attention in the context of pertussis vaccine development. In this review we summarize the available literature on the role of mucosal immunity in the prevention of
infection. In contrast to vaccination, natural infection in humans and experimental infections in animals induce strong secretory IgA responses in the naso-pharynx and in the lungs. Several studies have shown that secretory IgA may be instrumental in the control of
infection. Furthermore, studies in mouse models have revealed that
infection, but not immunization with current acellular pertussis vaccines induces resident memory T cells, which may also contribute to protection against colonization by
. As these resident memory T cells are long lived, vaccines that are able to induce them should provide long-lasting immunity. As of today, only one vaccine designed to induce potent mucosal immunity is in clinical development. This vaccine is a live attenuated
strain delivered nasally in order to mimic the natural route of infection. Due to its ability to induce mucosal immunity it is expected that this approach will contribute to improved control of pertussis.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Animals
/ Bordetella pertussis - immunology
/ Bordetella pertussis - pathogenicity
/ Disease
/ Humans
/ Immunity, Mucosal - immunology
/ Immunoglobulin A, Secretory - immunology
/ Immunoglobulin A, Secretory - metabolism
/ Lungs
/ Mice
/ Pertussis Vaccine - administration & dosage
/ Pertussis Vaccine - immunology
/ Pharynx
/ Respiratory Mucosa - immunology
/ Respiratory Mucosa - microbiology
/ tissue-resident memory T cells
/ Toxins
/ Vaccines
/ Vaccines, Attenuated - administration & dosage
/ Vaccines, Attenuated - immunology
/ Whooping Cough - microbiology
