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T Follicular Helper-Like Cells Are Involved in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
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T Follicular Helper-Like Cells Are Involved in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
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Journal Article
T Follicular Helper-Like Cells Are Involved in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
2018
Overview
Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) have been proved to be T cell-mediated autoimmune diseases. Recent researches indicate that humoral immunity is also involved in the pathogenesis of these disorders. T follicular helper (Tfh) cells are critical for B cell differentiation and antibody production. However, the role of Tfh cells in MS and EAE remains unclear. Here, we found elevated frequencies of CD4
CXCR5
PD-1
Tfh-like cells in both MS patients and EAE. In EAE mice, Tfh-like cells, together with B cells, were found in the ectopic lymphoid structures in spinal cords. Moreover, Tfh-like cells promoted the antibody production
IL-21/IL-21R and CD40 ligand/CD40 interaction and the synergy effect of STAT3 and non-canonical NF-κB signaling pathway inside B cells. Moreover, adoptive transfer of Tfh-like cells could increase the severity and delay the remission of EAE. In conclusion, our data indicate that Tfh-like cells contribute to the pathogenesis of EAE.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Adult
/ Animals
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - metabolism
/ Cells
/ Encephalomyelitis, Autoimmune, Experimental - etiology
/ Encephalomyelitis, Autoimmune, Experimental - metabolism
/ Encephalomyelitis, Autoimmune, Experimental - pathology
/ Experimental allergic encephalomyelitis
/ experimental autoimmune encephalomyelitis
/ Female
/ Germinal Center - immunology
/ Germinal Center - metabolism
/ Humans
/ Male
/ Mice
/ Multiple Sclerosis, Relapsing-Remitting
/ Myelin-Oligodendrocyte Glycoprotein - adverse effects
/ Peptide Fragments - adverse effects
/ Peptides
/ T-Lymphocytes, Helper-Inducer - immunology
