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TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling

by Gao, Xing , Tian, Zheng , Fan, Xue-Peng , Li, Cheng-Duo , Gu, Qing-Zhi , Nijiati, Abulimiti , Tao, Kai-Liang

in 1-Phosphatidylinositol 3-kinase / AKT protein / Bone cancer / Care and treatment / Cell adhesion & migration / Cell growth / Cell migration / Cell proliferation / Cell surface / Cell surface antigens / Cellular signal transduction / Chemotherapy / Development and progression / Genetic aspects / Health aspects / Infections / Innovations / Medical prognosis / Metastasis / Molecular modelling / Molecular targeted therapy / Osteosarcoma / Pathogenesis / Patients / phosphoinositide 3-kinase/protein kinase B / Sarcoma / Signal transduction / Studies / trophoblast cell surface antigen 2 / Tumors / Wound healing

2018

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TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling

by Gao, Xing , Tian, Zheng , Fan, Xue-Peng , Li, Cheng-Duo , Gu, Qing-Zhi , Nijiati, Abulimiti , Tao, Kai-Liang

2018

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TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling

by Gao, Xing , Tian, Zheng , Fan, Xue-Peng , Li, Cheng-Duo , Gu, Qing-Zhi , Nijiati, Abulimiti , Tao, Kai-Liang

2018

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Journal Article

TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling

Gao, Xing,

Tian, Zheng,

Fan, Xue-Peng,

Li, Cheng-Duo,

Gu, Qing-Zhi,

Nijiati, Abulimiti,

Tao, Kai-Liang

2018

Overview

Human trophoblast cell surface antigen 2 (TROP2) has been noted to serve an important role in the proliferation and migration of various types of human cancers. However, the potential role and the molecular mechanisms of TROP2 in osteosarcoma (OS) remain largely unclear. In the present study, high expression of TROP2 in human OS tissues and cell lines was observed. Overexpression of TROP2 promoted the proliferation and migration of OS cell lines, while TROP2 knockdown markedly decreased cell growth and migration. Furthermore, it was revealed that TROP2 overexpression significantly activated the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. Collectively, these results suggested that TROP2 may promote OS cell proliferation and migration via PI3K/AKT signaling and may serve as a novel treatment target for OS.

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Publisher

D.A. Spandidos,Spandidos Publications,Spandidos Publications UK Ltd

Subject

1-Phosphatidylinositol 3-kinase

/ AKT protein

/ Bone cancer

/ Care and treatment

/ Cell adhesion & migration

/ Cell growth

/ Cell migration