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MMP12 disrupts epithelial barrier integrity in oral lichen planus by degrading fibronectin

by Ge, Xuejun , Xie, Zhouqiao , Wang, Xiangyu , Ren, Xiuyun

in 631/80 / 692/308 / Basement membranes / Cell culture / Female / Fibronectin / Fibronectins - metabolism / Gum disease / Hospitals / Humanities and Social Sciences / Humans / Inflammatory diseases / Keratinocytes / Keratinocytes - metabolism / Keratinocytes - pathology / Lichen planus / Lichen Planus, Oral - metabolism / Lichen Planus, Oral - pathology / Lymphocytes / Lymphocytes T / Macrophages / Macrophages - metabolism / Male / Matrix metalloproteinase / Matrix Metalloproteinase 12 - metabolism / Matrix metalloproteinase-12 / Metalloproteinase / Middle Aged / Mouth Mucosa - metabolism / Mouth Mucosa - pathology / multidisciplinary / Oral cancer / Oral carcinoma / Oral diseases / Oral epithelial barrier / Oral lichen planus / Oral squamous cell carcinoma / Periodontitis / Proteolysis / Science / Science (multidisciplinary) / Squamous cell carcinoma

2024

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MMP12 disrupts epithelial barrier integrity in oral lichen planus by degrading fibronectin

by Ge, Xuejun , Xie, Zhouqiao , Wang, Xiangyu , Ren, Xiuyun

2024

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MMP12 disrupts epithelial barrier integrity in oral lichen planus by degrading fibronectin

by Ge, Xuejun , Xie, Zhouqiao , Wang, Xiangyu , Ren, Xiuyun

2024

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Journal Article

MMP12 disrupts epithelial barrier integrity in oral lichen planus by degrading fibronectin

Ge, Xuejun,

Xie, Zhouqiao,

Wang, Xiangyu,

Ren, Xiuyun

2024

Overview

Oral lichen planus (OLP) is a chronic inflammatory disorder featured with T lymphocytes infiltration and epithelial basement membrane breakdown. Although matrix metalloproteinase-12 (MMP12) is reported to be involved in the pathogenesis of oral diseases such as oral squamous cell carcinoma and periodontitis, the roles of MMP12 in the context of OLP remain poorly understood. Here, we demonstrate that MMP12 in macrophages derived from mucosal diseased tissues compromises the epithelial barrier integrity in OLP. The increased MMP12 facilitates fibronectin degradation in keratinocytes, leading to oral epithelial barrier disruption. Overexpression of fibronectin in oral keratinocytes prevents epithelial barrier from MMP12-induced damage. In addition, pharmacological inhibition of MMP12 reverses keratinocyte barrier disruption in a cell model. Altogether, our study reveals that MMP12 mediates oral epithelial barrier integrity in the setting of OLP.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ 692/308

/ Female

/ Fibronectins - metabolism