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Physiological Role of α -melanocyte-stimulating Hormone in Modulating the Secretion of Prolactin and Luteinizing Hormone in the Female Rat
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Physiological Role of α -melanocyte-stimulating Hormone in Modulating the Secretion of Prolactin and Luteinizing Hormone in the Female Rat
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Physiological Role of α -melanocyte-stimulating Hormone in Modulating the Secretion of Prolactin and Luteinizing Hormone in the Female Rat
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Journal Article
Physiological Role of α -melanocyte-stimulating Hormone in Modulating the Secretion of Prolactin and Luteinizing Hormone in the Female Rat
1984
Overview
Long-term ovariectomized (OVX) rats were injected in the third cerebral ventricle with 5 μ l of the globulin fraction of an antiserum raised against α -melanocyte-stimulating hormone (α -MSH) or an equal volume of the globulin fraction of normal rabbit serum (NRS). Immunoneutralization of brain α -MSH produced an increase in the area under the secretion curve of prolactin (Prl), the amplitude of Prl pulses, and mean plasma Prl (P < 0.01). In animals that had received two injections of NRS or anti-MSH and were subjected to a 2-min ether stress, Prl levels significantly increased within 5 minutes in the NRS-injected rats, whereas Prl levels in the antiserum-injected rats did not increase any further from the initially high baseline levels. The administration of antibodies against α -MSH produced a small increase (P < 0.05) in the area under the secretion of luteinizing hormone (LH) and mean plasma LH; however, the number of LH pulses was unaffected. We conclude that endogenous α -MSH of central origin is a physiological neuromodulator of release of Prl and LH in the OXV rat and is involved in the stress-induced release of Prl.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences
