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The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice
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The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice
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Journal Article
The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice
2025
Overview
Fear can be induced either directly through self-experience of aversive events or vicariously by observing conspecifics experiencing such events. The locus coeruleus-norepinephrine (LC-NA) system is crucial in fear responses and cognitive processes. We investigated whether the LC-NA system differentially processes these two types of fear, direct and vicarious in male mice. The results highlighted that the right hemisphere LC→anterior cingulate cortex pathway is uniquely crucial for vicarious fear, while the two inputs to the LC—from the bed nucleus of the stria terminalis (BNST) and the central amygdala (CeA)—differentially contribute to fear processing. The BNST plays a more targeted role in vicarious fear, and the CeA has a broader influence on fear in general. This underscores the complexity and specialization within the LC-NA system for fear-processing.
Fear arises directly or vicariously, with the LC-NA system involved in both. Here, the authors show that the right LC → ACC pathway is key for vicarious fear, while BNST and CeA provide distinct inputs to LC, highlighting its complex role in fear.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 14
/ 64/60
/ Amygdala
/ Animals
/ Central Amygdaloid Nucleus - physiology
/ Fear
/ Humanities and Social Sciences
/ Locus Coeruleus - physiology
/ Male
/ Mice
/ Neurons
/ Science
