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Voxelwise analysis of the central hearing pathway in senior dogs reveals changes associated with fractional lifespan
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Voxelwise analysis of the central hearing pathway in senior dogs reveals changes associated with fractional lifespan
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Journal Article
Voxelwise analysis of the central hearing pathway in senior dogs reveals changes associated with fractional lifespan
2024
Overview
Presbycusis, or age-related hearing loss, affects both elderly humans and dogs, significantly impairing their social interactions and cognition. In humans, presbycusis involves changes in peripheral and central auditory systems, with central changes potentially occurring independently. While peripheral presbycusis in dogs is well-documented, research on central changes remains limited. Diffusion tensor imaging (DTI) is a useful tool for detecting and quantifying cerebral white matter abnormalities. This study used DTI to explore the central auditory pathway of senior dogs, aiming to enhance our understanding of canine presbycusis. Dogs beyond 75% of their expected lifespan were recruited and screened with brainstem auditory evoked response testing to select dogs without severe peripheral hearing loss. Sixteen dogs meeting the criteria were scanned using a 3 T magnetic resonance scanner. Tract-based spatial statistics was used to analyze the central auditory pathways. A significant negative correlation between fractional lifespan and fractional anisotropy was found in the acoustic radiation, suggesting age-related white matter changes in the central auditory system. These changes, observed in dogs without severe peripheral hearing loss, may contribute to central presbycusis development.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/308
/ 692/617
/ Age
/ Animals
/ Auditory Pathways - diagnostic imaging
/ Auditory Pathways - physiopathology
/ Bats
/ Canine
/ Diffusion Tensor Imaging - methods
/ Dogs
/ Evoked Potentials, Auditory, Brain Stem - physiology
/ Female
/ Humanities and Social Sciences
/ Male
/ Presbycusis - diagnostic imaging
/ Presbycusis - physiopathology
/ Science
