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Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study
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Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study
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Journal Article
Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study
2024
Overview
The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval 0.37–0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/163
/ Colorectal Neoplasms - epidemiology
/ Colorectal Neoplasms - genetics
/ Female
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Gonadal Steroid Hormones - metabolism
/ Hormones
/ Humanities and Social Sciences
/ Humans
/ HUNT
/ Lung Neoplasms - epidemiology
/ Medicine
/ Mendelian Randomization Analysis
/ Nursing
/ Polymorphism, Single Nucleotide
/ Science
/ Sex Hormone-Binding Globulin - genetics
