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Development of anti-Crimean-Congo hemorrhagic fever virus Gc and NP-specific ELISA for detection of antibodies in domestic animal sera

by Charleston, Bryan , Hewson, Roger , Tchakarova, Simona R. , Lyons, Nicholas A. , Browning, Clare , Lambe, Teresa , Hannant, Kayleigh , Hughes, Ellen , Belij-Rammerstorfer, Sandra , Maze, Emmanuel A. , Willett, Brian , Carroll, Miles , Alexandrov, Tsviatko , Ludi, Anna B. , Mmbaga, Blandina T. , Thomas, Kelly M. , Wright, Daniel , Booth, George , Baker, Natalie , Saunders, Jack , Wilsden, Ginette , Limon, Georgina

in Animals / Antibodies / antibody response / Antigens / Arachnids / CCHFV Gc / CCHFV NP / Crimean hemorrhagic fever / Crimean-Congo hemorrhagic fever / Domestic animals / ELISA / Enzyme-linked immunosorbent assay / Epidemics / Fever / Glycoproteins / Heterogeneity / Immune response / Immunoglobulin G / Infectious diseases / Livestock / Proteins / Serological tests / Sheep / Vaccines / Vertebrates / Veterinary Science / Viruses

2022

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Development of anti-Crimean-Congo hemorrhagic fever virus Gc and NP-specific ELISA for detection of antibodies in domestic animal sera

2022

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Development of anti-Crimean-Congo hemorrhagic fever virus Gc and NP-specific ELISA for detection of antibodies in domestic animal sera

2022

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Journal Article

Development of anti-Crimean-Congo hemorrhagic fever virus Gc and NP-specific ELISA for detection of antibodies in domestic animal sera

Charleston, Bryan,

Hewson, Roger,

Tchakarova, Simona R.,

Lyons, Nicholas A.,

Browning, Clare,

Lambe, Teresa,

Hannant, Kayleigh,

Hughes, Ellen,

Belij-Rammerstorfer, Sandra,

Maze, Emmanuel A.,

Willett, Brian,

Carroll, Miles,

Alexandrov, Tsviatko,

Ludi, Anna B.,

Mmbaga, Blandina T.,

Thomas, Kelly M.,

Wright, Daniel,

Booth, George,

Baker, Natalie,

Saunders, Jack,

Wilsden, Ginette,

Limon, Georgina

2022

Overview

Crimean-Congo hemorrhagic fever (CCHF) is a priority emerging disease. CCHF, caused by the CCHF virus (CCHFV), can lead to hemorrhagic fever in humans with severe cases often having fatal outcomes. CCHFV is maintained within a tick-vertebrate-tick cycle, which includes domestic animals. Domestic animals infected with CCHFV do not show clinical signs of the disease and the presence of antibodies in the serum can provide evidence of their exposure to the virus. Current serological tests are specific to either one CCHFV antigen or the whole virus antigen. Here, we present the development of two in-house ELISAs for the detection of serum IgG that is specific for two different CCHFV antigens: glycoprotein Gc (CCHFV Gc) and nucleoprotein (CCHFV NP). We demonstrate that these two assays were able to detect anti-CCHFV Gc-specific and anti-CCHFV NP-specific IgG in sheep from endemic CCHFV areas with high specificity, providing new insight into the heterogeneity of the immune response induced by natural infection with CCHFV in domestic animals.

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Frontiers Media SA,Frontiers Media S.A

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