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Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents
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Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents
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Journal Article
Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents
2019
Overview
Numerous reports have shown that conjugated benzimidazole derivatives possess various kinds of biological activities, including anticancer properties. In this report, we designed and synthesized 24 new molecules comprising a benzimidazole ring, arene, and alkyl chain-bearing cyclic moieties. The results showed that the
-substituted benzimidazole derivatives bearing an alkyl chain and a nitrogen-containing 5- or 6-membered ring enhanced the cytotoxic effects on human breast adenocarcinoma (MCF-7) and human ovarian carcinoma (OVCAR-3) cell lines. Among the 24 synthesized compounds, (2
)-1-(1-(3-morpholinopropyl)-1
-benzimidazol-2 -yl)-3-phenyl-2-propen-1-one) (
) reduced the proliferation of MCF-7 and OVCAR-3 cell lines demonstrating superior outcomes to those of cisplatin.
Publisher
MDPI AG,MDPI
Subject
/ Benzimidazoles - chemical synthesis
/ Benzimidazoles - pharmacology
/ Breast
/ Breast Neoplasms - drug therapy
/ Breast Neoplasms - pathology
/ Cell Proliferation - drug effects
/ Cell Survival - drug effects
/ Chains
/ chalcone
/ Chalcones - chemical synthesis
/ Drug Screening Assays, Antitumor
/ Drugs
/ Female
/ Humans
/ Kinases
/ Nitrogen
/ Ovarian Neoplasms - drug therapy
/ Ovarian Neoplasms - pathology
