Journal Article

Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model

Chen, Zhaoliang, Zhao, Kui, Zhang, Cheng, Zhang, Chunmao, Cai, Zhuming, Chen, Ligong, Wang, Yingchun, Qiao, Sina, Meng, Lijia, Liu, Juxiang, Guo, Zhendong, Dong, Shishan, Cui, Huan

2022

Overview

Influenza virus is a serious threat to global human health and public health security. There is an urgent need to develop new anti-influenza drugs. Lentinan (LNT) has attracted increasing attention in recent years. As potential protective agent, LNT has been shown to have anti-tumor, anti-inflammatory, and antiviral properties. However, there has been no further research into the anti-influenza action of lentinan in vivo , and the mechanism is still not fully understood. In this study, the anti-influenza effect and mechanism of Lentinan were studied in the Institute of Cancer Research (ICR) mouse model. The results showed that Lentinan had a high degree of protection in mice against infection with influenza A virus, delayed the emergence of clinical manifestations, improved the survival rate of mice, significantly prolonged the middle survival days, attenuated the weight loss, and reduced the lung coefficient of mice. It alleviated the pathological damage of mice infected with the influenza virus and improved blood indices. Lentinan treatment considerably inhibited inflammatory cytokine (TNF-α, IL-1β, IL-4, IL-5, IL-6) levels in the serum and lung and improved IFN-γ cytokine levels, which reduced cytokine storms caused by influenza virus infection. The underlying mechanisms of action involved Lentinan inhibiting the inflammatory response by regulating the TLR4/MyD88 signaling pathway. This study provides a foundation for the clinical application of Lentinan, and provides new insight into the development of novel immunomodulators.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Aldehydes / Animals / Anti-Inflammatory Agents - pharmacology / Anti-Inflammatory Agents - therapeutic use / Anticoagulants / Antiviral activity / Antiviral agents / Avian flu / Blood tests / Cellular and Infection Microbiology / Cytokine storm / Cytokines - metabolism / Disease Models, Animal / Drug dosages / Eggs / Epidemics / Humans / ICR mouse model / Immunomodulation / Infections / Inflammation / Influenza A / influenza virus / Influenza, Human - drug therapy / Interleukins / Kinases / Laboratory animals / Lentinan / Lentinan - pharmacology / Lentinan - therapeutic use / Lungs / Mice / Mice, Inbred ICR / Mortality / MyD88 protein / Neoplasms / Orthomyxoviridae Infections - drug therapy / Public health / Signal transduction / Survival / TLR4 protein / TLR4/MyD88 signaling pathway / Toll-like receptors / Tumor necrosis factor-α / Viruses / γ-Interferon