Journal Article

O-GlcNAcylation and Its Role in Cancer-Associated Inflammation

Yu, Changmeng, Zhang, Yingyi, Deng, Xiaolian, Duan, Fangfang, Ouyang, Muzi, Zhang, Xudong

2022

Overview

Cancer cells, as well as surrounding stromal and inflammatory cells, form an inflammatory tumor microenvironment (TME) to promote all stages of carcinogenesis. As an emerging post-translational modification (PTM) of serine and threonine residues of proteins, O-linked-N-Acetylglucosaminylation (O-GlcNAcylation) regulates diverse cancer-relevant processes, such as signal transduction, transcription, cell division, metabolism and cytoskeletal regulation. Recent studies suggest that O-GlcNAcylation regulates the development, maturation and functions of immune cells. However, the role of protein O-GlcNAcylation in cancer-associated inflammation has been less explored. This review summarizes the current understanding of the influence of protein O-GlcNAcylation on cancer-associated inflammation and the mechanisms whereby O-GlcNAc-mediated inflammation regulates tumor progression. This will provide a theoretical basis for further development of anti-cancer therapies.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Amino acids / Angiogenesis / Breast cancer / cancer inflammation / Cancer therapies / Carcinogenesis / Cell division / Cytoskeleton / Enzymes / Fatty acids / Glucose / Glycosylation / HBP pathway / Humans / Immunology / Inflammation / Kinases / Liver cancer / Metabolism / Metastasis / N-Acetylglucosaminyltransferases - metabolism / Neoplasms / O-GlcNAcylation / Phosphorylation / Post-translation / post-translational modification (PTM) / Protein Processing, Post-Translational / Proteins / Proteins - metabolism / Signal Transduction / TME (tumor microenvironment) / Tumor Microenvironment / Tumors