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Tremella fuciformis Polysaccharides Inhibited Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice via Foxp3+ T Cells, Gut Microbiota, and Bacterial Metabolites
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Tremella fuciformis Polysaccharides Inhibited Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice via Foxp3+ T Cells, Gut Microbiota, and Bacterial Metabolites
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Journal Article
Tremella fuciformis Polysaccharides Inhibited Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice via Foxp3+ T Cells, Gut Microbiota, and Bacterial Metabolites
2021
Overview
Tremella fuciformis is an edible medicinal mushroom, and its polysaccharide components are found to confer various health benefits. This study identified the protective effects of polysaccharides of Tremella fuciformis (TPs) against dextran sulfate sodium (DSS)-induced colitis in mice. High dose of TPs (HTPs) could prevent the colon from shortening, reduce activity of colonic myeloperoxidase and serum diamine oxidase (DAO), decrease the concentration of D-lactate, and alleviate the colonic tissue damage in colitic mice. HTPs treatment stimulated Foxp3+T cells, and promoted the production of anti-inflammatory cytokines whereas it reduced the production of pro-inflammatory and the portion of immunoglobulin A (IgA)-coated bacteria, which was related to modulation of immune responses. 16S rRNA sequencing analysis showed that TPs could significantly increase gut community diversity, and restore the relative abundances of Lactobacillus, Odoribacter, Helicobacter, Ruminococcaceae, and Marinifilaceae. According to metabolomic analysis, HTPs induced specific microbial metabolites akin to that in normal mice. Tyrosine biosynthesis, tryptophan metabolism, and bile acid metabolism were influenced in the HTPs group compared with those in the DSS group. HTPs could alleviate DSS-induced colitis by immunoregulation and restored the gut microbiota and microbial metabolites. The results indicated that HTPs have potential to be developed as a food supplement to ameliorate intestinal diseases.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Anti-Inflammatory Agents - administration & dosage
/ Bile Acids and Salts - metabolism
/ Colitis
/ Colitis - chemically induced
/ Colon
/ Dextran
/ Dextran Sulfate - adverse effects
/ Female
/ Forkhead Transcription Factors - metabolism
/ Fungal Polysaccharides - administration & dosage
/ Fungal Polysaccharides - chemistry
/ Gastrointestinal Microbiome - drug effects
/ Gram-Negative Bacteria - metabolism
/ Gram-Positive Bacteria - metabolism
/ Mice
/ Protective Agents - administration & dosage
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Signal Transduction - drug effects
/ T-Lymphocytes, Regulatory - drug effects
/ T-Lymphocytes, Regulatory - immunology
/ Tremella
