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Fluconazole for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major
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Fluconazole for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major
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Journal Article
Fluconazole for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major
2002
Overview
This randomized trial evaluated the efficacy of 200 mg of fluconazole taken orally every day for six weeks as a treatment for cutaneous leishmaniasis. There were follow-up data on 145 patients, and all the parasites isolated were confirmed to be
Leishmania major
. Three months after treatment ended, there was complete healing of the lesions in 79 percent of those in the fluconazole group, as compared with only 34 percent of those in the placebo group.
Leishmaniasis is a major cause of illness and death and a top priority for the tropical disease program of the World Health Organization. The worldwide incidence of leishmaniasis is about 1.8 million new cases annually.
1
Pentavalent antimony compounds remain the main therapeutic agents for various forms of leishmaniasis. However, because of severe side effects and the requirement for parenteral administration, there has been an intensive search for alternative therapies, including oral agents for cutaneous leishmaniasis caused by
Leishmania major
.
2
The lesions of cutaneous leishmaniasis heal eventually — usually after several months. Mild disease is often managed with local care . . .
Publisher
Massachusetts Medical Society
Subject
/ Animals
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Antifungal Agents - administration & dosage
/ Antifungal Agents - therapeutic use
/ Biological and medical sciences
/ Female
/ Fluconazole - administration & dosage
/ Fluconazole - therapeutic use
/ Humans
/ Leishmaniasis, Cutaneous - drug therapy
/ Leishmaniasis, Cutaneous - epidemiology
/ Leishmaniasis, Cutaneous - parasitology
/ Male
