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Polymethoxyflavones from Kaempferia parviflora stimulate melanogenesis by blocking the TPC2 channel
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Polymethoxyflavones from Kaempferia parviflora stimulate melanogenesis by blocking the TPC2 channel
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Journal Article
Polymethoxyflavones from Kaempferia parviflora stimulate melanogenesis by blocking the TPC2 channel
2025
Overview
Kaempferia parviflora
, well-known as Thai ginseng (Krachaidum), has been used as a medicinal plant and food source for centuries. Its rhizome contains several flavonoids, particularly poly-
O
-methylated flavones (also known as polymethoxyflavones). We previously found that
K. parviflora
extract had a strong stimulatory effect on melanogenesis in B16F10 mouse melanoma cells. The aim of this study was to investigate the melanogenic stimulation exerted by various
O
-methylated flavonoids from
K. parviflora
in human melanoma cells and elucidate the mechanism of action of the most active compound. MNT-1 cells were used to screen for the most potent
O
-methylated flavonoid, and its effects on some key steps in melanin biosynthesis would subsequently be investigated. The poly-
O
-methylated flavone 3,5,7,3′,4′-pentamethoxyflavone (PMF) exhibited the strongest melanogenesis-stimulating activity among the 13
O
-methylated flavones isolated from
K. parviflora
. It was shown to enhance tyrosinase (TYR) activity by upregulating the levels of TYR and TYR-related protein 1 (TRP-1) via its inhibitory effect on two-pore channel 2 (TPC2). In conclusion, poly-
O
-methylated flavones, especially PMF, were suggested as a potential group of flavonoids that could stimulate melanin production by inhibiting the activity of the TPC2 channel, leading to increased TYR and TRP-1 activities.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
