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Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation

by Ljungman, Per , Wan, Hong , Marty, Francisco M , Ullmann, Andrew J , Snydman, David R , Boeckh, Michael , Badshah, Cyrus , Chemaly, Roy F , Mullane, Kathleen M , Teal, Valerie L , Haider, Shariq , Leavitt, Randi Y , Kartsonis, Nicholas A , Katayama, Yuta , Maertens, Johan , Dadwal, Sanjeet S , Brown, Janice , Kanda, Yoshinobu , Murata, Yoshihiko , Blumberg, Emily A , DiNubile, Mark J , Duarte, Rafael F , Einsele, Hermann

in Acetates - adverse effects / Acetates - therapeutic use / Adolescent / Adult / Aged / Antiviral Agents - adverse effects / Antiviral Agents - therapeutic use / Antiviral drugs / Clinical significance / Cyclosporins / Cytomegalovirus / Cytomegalovirus - genetics / Cytomegalovirus - isolation & purification / Cytomegalovirus Infections - epidemiology / Cytomegalovirus Infections - etiology / Cytomegalovirus Infections - prevention & control / Deoxyribonucleic acid / DNA / DNA, Viral - blood / Double-Blind Method / Edema / Female / Fibrillation / Gene loci / Hematopoietic Stem Cell Transplantation - adverse effects / Humans / Kaplan-Meier Estimate / Male / Middle Aged / Preventive medicine / Prophylaxis / Quinazolines - adverse effects / Quinazolines - therapeutic use / Stem cell transplantation / Stem cells / Terminase / Transplantation / Transplants & implants / Viremia / Vomiting / Young Adult

2017

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Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation

2017

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2017

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Journal Article

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation

Ljungman, Per,

Wan, Hong,

Marty, Francisco M,

Ullmann, Andrew J,

Snydman, David R,

Boeckh, Michael,

Badshah, Cyrus,

Chemaly, Roy F,

Mullane, Kathleen M,

Teal, Valerie L,

Haider, Shariq,

Leavitt, Randi Y,

Kartsonis, Nicholas A,

Katayama, Yuta,

Maertens, Johan,

Dadwal, Sanjeet S,

Brown, Janice,

Kanda, Yoshinobu,

Murata, Yoshihiko,

Blumberg, Emily A,

DiNubile, Mark J,

Duarte, Rafael F,

Einsele, Hermann

2017

Overview

CMV infection is a common complication in patients undergoing hematopoietic-cell transplantation. The incidence of CMV infection was 23 percentage points lower with prophylactic letermovir, a CMV–terminase complex inhibitor, than with placebo, with only low-level toxic effects.

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Publisher

Massachusetts Medical Society

Subject

Acetates - adverse effects

/ Acetates - therapeutic use

/ Adolescent

/ Adult

/ Aged

/ Antiviral Agents - adverse effects

/ Antiviral Agents - therapeutic use