Asset Details
Do you wish to reserve the book?
Immunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Immunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response
Do you wish to request the book?
Immunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Immunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response
2025
Overview
Acromegaly, caused by growth hormone-secreting pituitary tumors, often causes significant challenges in its management due to poor surgical outcomes and resistance to pharmacological treatment. The present study aims to explore the expression of Filamin A (FLNA), a cytoskeletal protein involved in somatostatin receptor signaling, and its clinical relevance in acromegaly. We conducted immunohistochemical (IHC) study on 34 GH-secreting pituitary tumors to evaluate FLNA expression intensity and its associations with somatostatin receptors (SSTR2, SSTR5), E-Cadherin, tumor characteristics obtained through imaging studies, and pharmacological treatment responses. Our findings revealed a 100% FLNA positivity rate, with moderate to strong FLNA expression correlating significantly with SSTR5 expression and the presence of suprasellar tumor extension, indicating a potential role in tumor invasiveness. Moreover, patients with macrodenomas presented significantly higher FLNA intensity compared to the ones with microadenomas. FLNA expression showed no significant association with SSTR2, E-Cadherin, surgical cure rate or first-generation somatostatin receptor ligand (fgSRL) responses. However, the series of patients treated with Pasireotide (
n
= 4) demonstrated a trend suggesting better biochemical control with higher FLNA expression. In conclusion, our results suggest that FLNA may be associated with tumor invasiveness in GH-secreting pituitary tumors. While data on Pasireotide-treated patients are exploratory, further studies are needed to assess FLNA’s potential as a treatment response marker in acromegaly.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Aged
/ Cloning
/ Dopamine
/ Female
/ Growth Hormone-Secreting Pituitary Adenoma - metabolism
/ Growth Hormone-Secreting Pituitary Adenoma - pathology
/ Humanities and Social Sciences
/ Humans
/ Ligands
/ Male
/ Patients
/ Pituitary Neoplasms - metabolism
/ Pituitary Neoplasms - pathology
/ Proteins
/ Receptors, Somatostatin - metabolism
/ Science
/ Somatostatin - analogs & derivatives
/ Somatostatin - therapeutic use
/ Surgery
/ Tumors
