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Sparstolonin B attenuates MRSA-induced wound and peritonitis infection: in vivo, phytochemical, and computational investigation
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Sparstolonin B attenuates MRSA-induced wound and peritonitis infection: in vivo, phytochemical, and computational investigation
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Journal Article
Sparstolonin B attenuates MRSA-induced wound and peritonitis infection: in vivo, phytochemical, and computational investigation
2025
Overview
The unprecedented dissemination of antibiotic resistance announces a close post antibiotic era, thus exploring effective alternatives is urgent. Natural products are untapped alternatives that could offer effective alternatives with low costs. Sparastolonin B (SsnB) is a natural anthracene-derivative with a reported anti-inflammatory activity; however, its potential antibacterial activity is still under-explored. Here, we investigated both antibacterial and anti-inflammatory activity of SsnB in vitro
,
in vivo and in silico. In vitro, SsnB showed a specific antibacterial activity against Gram-positive bacteria with MIC range of 1–4 µg/ml against
S. aureus
and
E. faecalis
. Furthermore, it displayed a profound antibacterial activity against the clinical MRSA strain K15 in both wound infection, and peritonitis infection models with overall bacterial count reductions up to 1.21 and 1.23 log-units respectively. In addition, it has significantly improved wound healing and tissue repair rates compared to the un-treated group in wound infection model. SsnB has also significantly down-regulated the expression of inflammatory mediators, TLR-2, MCP-1, CXCL-1, CXCL-2, IL-6 and IL-1β, in the treated rabbits highlighting its potential anti-inflammatory activity. Finally, in silico analysis has predicted Gyr-B as a potential target for the observed SsnB antibacterial activity. To conclude, SsnB is a promising natural compound with a dual antibacterial and anti-inflammatory activities, suggesting it as a good candidate for subsequent clinical investigation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Anti-Inflammatory Agents - pharmacology
/ Bacteria
/ Docking
/ E coli
/ Gyrase-B
/ Humanities and Social Sciences
/ Male
/ Methicillin-Resistant Staphylococcus aureus - drug effects
/ Monocyte chemoattractant protein 1
/ Phytochemicals - pharmacology
/ Rabbits
/ Science
/ Staphylococcal Infections - drug therapy
/ Staphylococcal Infections - microbiology
/ Wound Healing - drug effects
