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Integrative omics of the genetic basis for wheat WUE and drought resilience reveal the function of TaMYB7-A1
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Integrative omics of the genetic basis for wheat WUE and drought resilience reveal the function of TaMYB7-A1
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Journal Article
Integrative omics of the genetic basis for wheat WUE and drought resilience reveal the function of TaMYB7-A1
2025
Overview
Improving wheat drought resilience and water use efficiency (WUE) is critical for sustaining productivity under increasing water scarcity. Here, we integrate genome-wide association study (GWAS), expression quantitative trait locus (eQTL) mapping, population-transcriptome analysis, and summary-data-based mendelian randomization (SMR), followed by functional validation using indexed EMS mutants and transgenic lines, to systematically identify key WUE regulators. GWAS across water conditions in 228 accessions identifies 73 quantitative trait loci (QTLs) for WUE-traits. Transcriptome profiling of 110 diverse accessions reveals 28 drought-responsive modules. eQTL mapping uncovers 146,966 regulatory variants, including condition-specific hotspots associated with key drought-related pathways. Integrative analysis underscores 85 high-confidence candidate genes, notably
TaMYB7-A1
. Overexpression of
TaMYB7-A1
enhances photosynthesis, WUE, root development, and grain yield under drought condition by activating
TaPIP2;2-B1
(water transport),
TaRD20-D1
(stomatal regulation), and
TaABCB4-B1
(root growth), reflecting reduced water loss and improved physiological resilience. Our study presents a comprehensive regulatory map and robust targets for wheat drought adaptation and resilient cultivar breeding.
Multi-omics integrating genetic, transcriptomic, and phenotypic variation, coupled with mutant validation, identified 85 high-confidence WUE and drought resilience genes in wheat, with TaMYB7-A1 confirmed as a key regulator.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/43
/ 38/91
/ Biomass
/ Corn
/ Crops
/ Drought
/ Droughts
/ Gene Expression Regulation, Plant
/ Genes
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Humanities and Social Sciences
/ Mapping
/ Mendelian Randomization Analysis
/ Mutants
/ Plants, Genetically Modified
/ Proteins
/ Quantitative Trait Loci - genetics
/ Science
/ Stomata
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ Wheat
