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Insight into the phytochemical profile and antimicrobial activities of Amomum subulatum and Amomum xanthioides: an in vitro and in silico study
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Insight into the phytochemical profile and antimicrobial activities of Amomum subulatum and Amomum xanthioides: an in vitro and in silico study
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Journal Article
Insight into the phytochemical profile and antimicrobial activities of Amomum subulatum and Amomum xanthioides: an in vitro and in silico study
2023
Overview
Medicinal plants have been considered as potential source of therapeutics or as starting materials in drugs formulation.
The current study aims to shed light on the therapeutic potential of the
and
Fruits by analyzing the phytochemical composition of their seeds and fruits using gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) techniques to determine the presence of bioactive components such as flavonoids, phenols, vitamins, steroids, and essential oils.
The protein content is usually higher than the total lipids in both species except the fruit of
which contain more lipids than proteins. The total protein contents for
were 235.03 ± 21.49 and 227.49 ± 25.82 mg/g dry weight while for
were 201.9 ± 37.79 and 294.99 ± 37.93 mg/g dry weight for seeds and fruit, respectively. The Carvacrol levels in
is 20 times higher than that in
. Lower levels of α-Thujene, Phyllanderenes, Ascaridole, and Pinocarvone were also observed in both species. According to DPPH (2,2-diphenylpicrylhydrazyl) assay, seed the extract of
exhibited the highest antioxidant activity (78.26±9.27 %) followed by the seed extract of
(68.21±2.56 %). Similarly, FRAP (Ferric Reducing Antioxidant Power) assay showed that the highest antioxidant activity was exhibited by the seed extract of the two species; 20.14±1.11 and 21.18±1.04 µmol trolox g-1 DW for
and
, respectively. In terms of anti-lipid peroxidation, relatively higher values were obtained for the fruit extract of
(6.08±0.35) and the seed extract of
(6.11±0.55). Ethanolic seed extracts of
had the highest efficiency against four Gram-negative bacterial species which causes serious human diseases, namely
,
,
, and
. In addition,
was also inhibited by the fruit extract of both
and
. For the seed extract of
, large inhibition zones were formed against
and the fungus
. Finally, we have
explored the mode of action of these plants by performing detailed molecular modeling studies and showed that the antimicrobial activities of these plants could be attributed to the high binding affinity of their bioactive compounds to bind to the active sites of the sterol 14-alpha demethylase and the transcriptional regulator MvfR.
These findings demonstrate the two species extracts possess high biological activities and therapeutical values, which increases their potential value in a number of therapeutic applications.
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