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Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote Acinetobacter baumannii biofilm formation
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Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote Acinetobacter baumannii biofilm formation
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Journal Article
Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote Acinetobacter baumannii biofilm formation
2025
Overview
Acinetobacter baumannii
is the causative agent of a wide range of nosocomial and community-acquired infections that remain extremely difficult to treat due largely to its antibiotic resistance contributed, in part, by biofilm formation. We find that the prototypic human neutrophil α-defensin HNP1, present in the bronchoalveolar lavage fluids from
Acinetobacter baumannii
-infected patients, promotes
Acinetobacter baumannii
biofilm formation through interactions with the bacterial outer membrane protein OmpA. As a result of HNP1-enhanced biofilm formation,
Acinetobacter baumannii
becomes more tolerant to antibiotics and more readily colonizes host cells and tissues. These unexpected findings contrast the protective roles HNP1 plays in innate immunity against microbial infection, showcasing an example of the host-pathogen arms race where a host defense peptide is exploited by a microbe for pathogenicity.
Acinetobacter baumannii
is an opportunistic pathogen that causes nosocomial and community-acquired infections. Here, the authors determine that human neutrophil α-defensin HNP1 can promote
A. baumannii biofilm
formation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 14/28
/ 38/88
/ 45/23
/ 45/91
/ 82/16
/ 82/29
/ 82/58
/ 82/80
/ 82/83
/ Acinetobacter baumannii - drug effects
/ Acinetobacter baumannii - metabolism
/ Acinetobacter baumannii - pathogenicity
/ Acinetobacter baumannii - physiology
/ Acinetobacter Infections - immunology
/ Acinetobacter Infections - metabolism
/ Acinetobacter Infections - microbiology
/ alpha-Defensins - immunology
/ alpha-Defensins - metabolism
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Bacterial Outer Membrane Proteins - metabolism
/ Biofilms
/ Biofilms - growth & development
/ Bronchoalveolar Lavage Fluid - chemistry
/ Bronchus
/ Humanities and Social Sciences
/ Humans
/ Lavage
/ Peptides
/ Proteins
/ Scanning electron microscopy
/ Science
