Asset Details
Do you wish to reserve the book?
A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men
Do you wish to request the book?
A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men
2026
Overview
Chronic prostatitis/chronic pelvic pain syndrome is common, and it impacts men’s health and quality of life. The genetic basis of this condition remains largely unknown. Here, we conduct a GWAS using data from the Million Veteran Program of over 590,000 men of European, African, and Hispanic ancestry, including 14,575 chronic prostatitis/chronic pelvic pain syndrome cases. The multi-ancestry analysis identifies eight novel loci associated with chronic prostatitis/chronic pelvic pain syndrome risk, an increase from three significant genome-wide loci found in the European participants alone. We also estimate the genetic correlations between chronic prostatitis/chronic pelvic pain syndrome and 12 phenotypes. Notably, the genetic correlation between chronic prostatitis/chronic pelvic pain syndrome and prostate cancer is not significant. Further, Mendelian randomization shows a significant, potentially bidirectional causal relationship between chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia, but not between chronic prostatitis/chronic pelvic pain syndrome and prostate cancer, suggesting a complex interplay between chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. Results of bivariate causal mixture modeling indicate that some of the same genetic variants likely contribute to the development of chronic prostatitis/chronic pelvic pain syndrome, benign prostatic hyperplasia, and prostate cancer.
The genetic basis of chronic prostatitis/chronic pelvic pain syndrome remains poorly understood. Here, the authors present a multi-ancestry GWAS of this syndrome, identifying eight loci linked with higher risk.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/43
/ Adult
/ Age
/ Aged
/ Black or African American - genetics
/ Etiology
/ Genes
/ Genetic Predisposition to Disease
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Hispanic or Latino - genetics
/ Humanities and Social Sciences
/ Humans
/ Male
/ Mendelian Randomization Analysis
/ Pain
/ Polymorphism, Single Nucleotide
/ Post traumatic stress disorder
/ Prostatic Hyperplasia - genetics
/ Prostatic Neoplasms - genetics
/ Science
