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Placement and orientation of individual DNA shapes on lithographically patterned surfaces
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Placement and orientation of individual DNA shapes on lithographically patterned surfaces
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Journal Article
Placement and orientation of individual DNA shapes on lithographically patterned surfaces
2009
Overview
Artificial DNA nanostructures
1
,
2
show promise for the organization of functional materials
3
,
4
to create nanoelectronic
5
or nano-optical devices. DNA origami, in which a long single strand of DNA is folded into a shape using shorter ‘staple strands’
6
, can display 6-nm-resolution patterns of binding sites, in principle allowing complex arrangements of carbon nanotubes, silicon nanowires, or quantum dots. However, DNA origami are synthesized in solution and uncontrolled deposition results in random arrangements; this makes it difficult to measure the properties of attached nanodevices or to integrate them with conventionally fabricated microcircuitry. Here we describe the use of electron-beam lithography and dry oxidative etching to create DNA origami-shaped binding sites on technologically useful materials, such as SiO
2
and diamond-like carbon. In buffer with ∼100 mM MgCl
2
, DNA origami bind with high selectivity and good orientation: 70–95% of sites have individual origami aligned with an angular dispersion (±1 s.d.) as low as ±10° (on diamond-like carbon) or ±20° (on SiO
2
).
Individual DNA origami shapes can be positioned and aligned on technologically useful substrates that have been patterned using electron-beam lithography and dry oxidative etching.
Publisher
Nature Publishing Group UK,Nature Publishing Group
