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IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses
by
Velez, Tania E.
, Hollinger, Maile K.
, Kennedy, Domenick E.
, Sperling, Anne I.
, Moon, James J.
, Wang, Esther
, Clark, Marcus R.
, Hrusch, Cara L.
, Camacho, Daniel F.
, Krishack, Paulette A.
, Darnell, Eli P.
, Howard, Chanie L.
in
Allergens
/ Allergies
/ Animals
/ Antigen presentation
/ Cdc2 protein
/ Cells
/ Dendritic Cells
/ Effector cells
/ Gene Expression Regulation
/ Immune response
/ Immunologic Memory
/ Immunological memory
/ Immunology
/ Infections
/ Inflammation
/ Interferon regulatory factor
/ Interferon regulatory factor 4
/ Interferon Regulatory Factors - genetics
/ Interferon Regulatory Factors - metabolism
/ Lung - pathology
/ Lungs
/ Lymph nodes
/ Lymphatic system
/ Lymphocytes
/ Lymphocytes T
/ Memory cells
/ Memory T Cells - immunology
/ Mice
/ Recall
/ Th2 Cells
/ Transcription factors
/ Vagina
2022
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IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses
by
Velez, Tania E.
, Hollinger, Maile K.
, Kennedy, Domenick E.
, Sperling, Anne I.
, Moon, James J.
, Wang, Esther
, Clark, Marcus R.
, Hrusch, Cara L.
, Camacho, Daniel F.
, Krishack, Paulette A.
, Darnell, Eli P.
, Howard, Chanie L.
in
Allergens
/ Allergies
/ Animals
/ Antigen presentation
/ Cdc2 protein
/ Cells
/ Dendritic Cells
/ Effector cells
/ Gene Expression Regulation
/ Immune response
/ Immunologic Memory
/ Immunological memory
/ Immunology
/ Infections
/ Inflammation
/ Interferon regulatory factor
/ Interferon regulatory factor 4
/ Interferon Regulatory Factors - genetics
/ Interferon Regulatory Factors - metabolism
/ Lung - pathology
/ Lungs
/ Lymph nodes
/ Lymphatic system
/ Lymphocytes
/ Lymphocytes T
/ Memory cells
/ Memory T Cells - immunology
/ Mice
/ Recall
/ Th2 Cells
/ Transcription factors
/ Vagina
2022
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IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses
by
Velez, Tania E.
, Hollinger, Maile K.
, Kennedy, Domenick E.
, Sperling, Anne I.
, Moon, James J.
, Wang, Esther
, Clark, Marcus R.
, Hrusch, Cara L.
, Camacho, Daniel F.
, Krishack, Paulette A.
, Darnell, Eli P.
, Howard, Chanie L.
in
Allergens
/ Allergies
/ Animals
/ Antigen presentation
/ Cdc2 protein
/ Cells
/ Dendritic Cells
/ Effector cells
/ Gene Expression Regulation
/ Immune response
/ Immunologic Memory
/ Immunological memory
/ Immunology
/ Infections
/ Inflammation
/ Interferon regulatory factor
/ Interferon regulatory factor 4
/ Interferon Regulatory Factors - genetics
/ Interferon Regulatory Factors - metabolism
/ Lung - pathology
/ Lungs
/ Lymph nodes
/ Lymphatic system
/ Lymphocytes
/ Lymphocytes T
/ Memory cells
/ Memory T Cells - immunology
/ Mice
/ Recall
/ Th2 Cells
/ Transcription factors
/ Vagina
2022
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IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses
Journal Article
IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses
2022
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Overview
Expression of the transcription factor interferon regulatory factor 4 (IRF4) is required for the development of lung conventional DCs type 2 (cDC2s) that elicit Th2 responses, yet how IRF4 functions in lung cDC2s throughout the acute and memory allergic response is not clear. Here, we used a mouse model that loses IRF4 expression after lung cDC2 development to demonstrate that mice with IRF4-deficient DCs display impaired memory responses to allergen. This defect in the memory response was a direct result of ineffective Th2 induction and impaired recruitment of activated effector T cells to the lung after sensitization. IRF4-deficient DCs demonstrated defects in their migration to the draining lymph node and in T cell priming. Finally, T cells primed by IRF4-competent DCs mediated potent memory responses independently of IRF4-expressing DCs, demonstrating that IRF4-expressing DCs are not necessary during the memory response. Thus, IRF4 controlled a program in mature DCs governing Th2 priming and effector responses, but IRF4-expressing DCs were dispensable during tissue-resident memory T cell-dependent memory responses.
Publisher
American Society for Clinical Investigation,American Society for Clinical investigation
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