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Central Precocious Puberty : Treatment with Triptorelin 11.25 mg
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Central Precocious Puberty : Treatment with Triptorelin 11.25 mg
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Central Precocious Puberty : Treatment with Triptorelin 11.25 mg
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Journal Article
Central Precocious Puberty : Treatment with Triptorelin 11.25 mg
2012
Overview
Background. Few data are available on quarterly 11.25 mg GnRH analog treatment in central precocious puberty (CPP). Aim. To assess the efficacy of triptorelin 11.25 mg in children with CPP. Patients. 17 patients (16 females) with CPP (7.9±0.9 years) were treated with triptorelin 11.25 mg/90 days. Methods. Gonadotropins, basal-, and GnRH-stimulated peak, gonadal steroids, and pubertal signs were assessed at preinclusion and at inclusion visit, 3 months, 6 months, and 12 months of treatment. Results. At 3, 6, and 12 months, all patients had suppressed LH peak (<3 IU/L after GnRH stimulation), as well as prepubertal oestradiol levels. Mean LH peak values after GnRH test significantly decreased from 25.7±16.5 IU/L at baseline to 0.9±0.5 IU/L at M3 (P<0.0001); they did not significantly changed at M6 and M12. Conclusions. Triptorelin 11.25 mg/90 days efficiently suppressed the pituitary-gonadal axis in children with CPP from first administration.
Publisher
Hindawi Puplishing Corporation,The Scientific World Journal,John Wiley & Sons, Inc,Wiley
Subject
/ Age
/ Boys
/ Child
/ Children
/ Female
/ Follicle Stimulating Hormone - metabolism
/ Gonadotropin-releasing hormone
/ Gonadotropin-Releasing Hormone - blood
/ Humans
/ Luteinizing Hormone - metabolism
/ Luteolytic Agents - therapeutic use
/ Male
/ Methods
/ Patients
/ Pituitary Gland - metabolism
/ Puberty
/ Puberty, Precocious - drug therapy
/ Steroids
/ Studies
