Journal Article

Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials. Bridging Clinical and Patient Perspectives

Fowler, Stephen J., Wagers, Scott, Akuthota, Praveen, Pavord, Ian D., Brown, Louise, Castro, Mario, Walker, Samantha, Kraft, Monica, Peters, Michael C., Siddiqui, Salman, Jarjour, Nizar N., Winders, Tonya A., Heaney, Liam G., Denlinger, Loren C., Shaw, Dominick E.

2019

Overview

[...]we highlight the importance of collaboration in interdisciplinary large-scale consortia to enable precision medicine trials. [...]basic research to fully elucidate type 2 pathways in severe asthma, combined with the development of more precise companion diagnostics that dissect these pathways, are urgently required. Targeting the Systemic Inflammation of Obesity Obesity is a key risk factor for developing severe asthma, and patients with severe asthma are frequently characterized by high body mass index and other obesity-associated comorbidities. Because obesity induces a state of low-grade systemic inflammation, it is intriguing to consider the possibility that obesity-associated inflammation may cause airway pathology in asthma. The Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes-Innovative Medicines Initiative and Severe Asthma Research Program projects have been deemed as highly successful collaborative projects (54). [...]future joint efforts in severe asthma clinical trials will reach their full potential only if they follow established principles for collaboration in a consortium.

• Publisher: Oxford University Press,American Thoracic Society
• Subject: Adult / Aged / Aged, 80 and over / Anti-Asthmatic Agents - therapeutic use / Asthma / Asthma - drug therapy / Asthma - genetics / Biomarkers / Cancer therapies / Collaboration / Cytokines / Drug dosages / Female / Humans / Immunoglobulins / Immunophenotyping / Inflammation / Male / Middle Aged / Patients / Practice Guidelines as Topic / Precision medicine / Precision Medicine - standards / Pulmonary / Workshops