Asset Details
Do you wish to reserve the book?
Whole genome analysis of two sympatric human Mansonella: Mansonella perstans and Mansonella sp “DEUX”
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Whole genome analysis of two sympatric human Mansonella: Mansonella perstans and Mansonella sp “DEUX”
Do you wish to request the book?
Whole genome analysis of two sympatric human Mansonella: Mansonella perstans and Mansonella sp “DEUX”
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Whole genome analysis of two sympatric human Mansonella: Mansonella perstans and Mansonella sp “DEUX”
2023
Overview
species are filarial parasites that infect humans worldwide. Although these infections are common, knowledge of the pathology and diversity of the causative species is limited. Furthermore, the lack of sequencing data for
species, shows that their research is neglected. Apart from Mansonella perstans, a potential new species called
sp \"DEUX\" has been identified in Gabon, which is prevalent at high frequencies. We aimed to further determine if
sp \"DEUX\" is a genotype of M.
, or if these are two sympatric species.
We screened individuals in the area of Fougamou, Gabon for Mansonella mono-infections and generated de novo assemblies from the respective samples. For evolutionary analysis, a phylogenetic tree was reconstructed, and the differences and divergence times are presented. In addition, mitogenomes were generated and phylogenies based on 12S rDNA and cox1 were created.
We successfully generated whole genomes for M. perstans and
sp \"DEUX\". Phylogenetic analysis based on annotated protein sequences, support the hypothesis of two distinct species. The inferred evolutionary analysis suggested, that M. perstans and
sp \"DEUX\" separated around 778,000 years ago. Analysis based on mitochondrial marker genes support our hypothesis of two sympatric human Mansonella species.
The results presented indicate that
sp \"DEUX\" is a new
species. These findings reflect the neglect of this research topic. And the availability of whole genome data will allow further investigations of these species.
