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A recombinant Modified Vaccinia virus Ankara expressing prME of tick-borne encephalitis virus affords mice full protection against TBEV infection

by Baumgärtner, Wolfgang , Beicht, Jana , Rimmelzwaan, Guus F. , Prajeeth, Chittappen Kandiyil , Zdora, Isabel , Gerlach, Thomas , Osterhaus, Albert D. M. E. , Kubinski, Mareike , Tscherne, Alina , Sutter, Gerd , Biermann, Jeannine , Puff, Christina

in Animals / Antibodies / Antibodies, Neutralizing / Antibodies, Viral / Arachnids / Asymptomatic / Central nervous system / Coronaviruses / Cytomegalovirus / Disease transmission / Embryos / Encephalitis / Encephalitis Viruses, Tick-Borne - genetics / FSME-IMMUN / Genomes / Humans / Immunogenicity / Immunology / Infections / Licenses / Lymphocytes / Mice / MVA / Pathogens / Peptides / protection / Proteins / Respiratory diseases / TBEV / Tick-borne encephalitis / Vaccination / Vaccines / Vaccinia virus - genetics / Viral Vaccines / Virulence / virus-neutralizing antibodies / Viruses / Zoonoses

2023

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A recombinant Modified Vaccinia virus Ankara expressing prME of tick-borne encephalitis virus affords mice full protection against TBEV infection

2023

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A recombinant Modified Vaccinia virus Ankara expressing prME of tick-borne encephalitis virus affords mice full protection against TBEV infection

2023

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Journal Article

A recombinant Modified Vaccinia virus Ankara expressing prME of tick-borne encephalitis virus affords mice full protection against TBEV infection

Baumgärtner, Wolfgang,

Beicht, Jana,

Rimmelzwaan, Guus F.,

Prajeeth, Chittappen Kandiyil,

Zdora, Isabel,

Gerlach, Thomas,

Osterhaus, Albert D. M. E.,

Kubinski, Mareike,

Tscherne, Alina,

Sutter, Gerd,

Biermann, Jeannine,

Puff, Christina

2023

Overview

Tick-borne encephalitis virus (TBEV) is an important human pathogen that can cause a serious disease involving the central nervous system (tick-borne encephalitis, TBE). Although approved inactivated vaccines are available, the number of TBE cases is rising, and breakthrough infections in fully vaccinated subjects have been reported in recent years. In the present study, we generated and characterized a recombinant Modified Vaccinia virus Ankara (MVA) for the delivery of the pre-membrane (prM) and envelope (E) proteins of TBEV (MVA-prME). MVA-prME was tested in mice in comparison with a licensed vaccine FSME-IMMUN® and proved to be highly immunogenic and afforded full protection against challenge infection with TBEV. Our data indicate that MVA-prME holds promise as an improved next-generation vaccine for the prevention of TBE.

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Publisher

Frontiers Media SA,Frontiers Media S.A

Subject

Animals

/ Antibodies

/ Antibodies, Neutralizing

/ Antibodies, Viral

/ Arachnids

/ Asymptomatic

/ Central nervous system