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Influence of CagA-positive Helicobacter pylori strains on atherosclerotic carotid disease
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Influence of CagA-positive Helicobacter pylori strains on atherosclerotic carotid disease
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Journal Article
Influence of CagA-positive Helicobacter pylori strains on atherosclerotic carotid disease
2011
Overview
Citotoxin-associated gene-A (CagA)-positive
Helicobacter pylori
strains have been associated with occurrence and destabilization of coronary atherosclerotic plaques. However, data on the relationship between CagA-positive
H. pylori
infection and carotid artery instability are lacking. Thus, the role of CagA antigen in patients with symptomatic and asymptomatic carotid atherosclerotic plaques was investigated. A total of 64 patients with advanced carotid artery stenosis, including 33 patients with symptomatic and 31 patients with asymptomatic internal carotid artery stenosis, verified by duplex ultrasound, all undergoing carotid endarterectomy, were studied. The control group consisted of 65 subjects without a history or presence of vascular diseases. Serology for
H. pylori
and CagA antigen was assessed in all participants. Specimens of atherosclerotic plaques obtained from all patients during carotid endarterectomy were analyzed immunohistochemically using anti-CagA monoclonal antibodies. The ultrasonographic plaque characteristics were also estimated. CagA antibody titers were significantly higher in symptomatic patients (8.8; range, 5.8–32.7) compared to asymptomatic patients (4.7; range, 2.1–8.8;
P
= 0.005) and the control group (5.0; range 2.2–7.9;
P
< 0.001). There was significant difference in echolucency (≥25% soft material) between the symptomatic and asymptomatic groups (
P
= 0.034) by ultrasonographic evaluation. Positive immunoreactivity between monoclonal CagA antibodies and antigens within atherosclerotic specimens was significantly higher among symptomatic patients compared to asymptomatic patients (97.0 vs. 74.2%;
P
= 0.009).
H. pylori
may play a role in the pathogenesis of the atherosclerotic process due to autoimmune mechanisms and even contribute to destabilization of carotid atherosclerotic plaques.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Antigens
/ Antigens, Bacterial - immunology
/ Atherosclerosis - microbiology
/ Bacterial Proteins - immunology
/ Biological and medical sciences
/ Carotid Artery Diseases - immunology
/ Carotid Artery Diseases - microbiology
/ Carotid Artery Diseases - pathology
/ Disease
/ Female
/ Helicobacter Infections - complications
/ Helicobacter Infections - immunology
/ Helicobacter pylori - immunology
/ Humans
/ Ischemia
/ Male
/ Medicine
/ Molecular Mimicry - immunology
/ Plaque, Atherosclerotic - microbiology
/ Plaque, Atherosclerotic - pathology
/ Stroke
/ Ulcers
