Journal Article

The Relationship of Functional Status of Cortisol, Testosterone, and Parameters of Metabolic Syndrome in Male Schizophrenics

Han, Yi, Liu, Li, Zhu, Yuncheng, Ji, Haifeng, Jiang, Xixi

2020

Overview

Background. The cross-sectional study is aimed at investigating the relationship between cortisol, testosterone, and metabolic characteristics among male schizophrenics. Methods. 174 patients were grouped based on their risk of metabolic syndrome (MetS) into the non-MetS, high-risk-MetS (HR-MetS), or MetS groups. Metabolic indices (body mass index (BMI), mean arterial pressure (MAP), cholesterol, triglyceride, and fasting blood glucose (FBG)) were associated with cortisol and testosterone levels using correlation analysis. Multiple linear regression analysis was used to associate the correlations between the WHO Quality of Life–BREF (WHOQOL–BREF) score and the five metabolic indices. Results. The WHOQOL–BREF score for the non-MetS group significantly differed from the scores of the HR-MetS and MetS groups. The triglyceride level was positively correlated with the cortisol level, while all five metabolic indices were negatively correlated with testosterone level. Stepwise regression analysis produced a model predicting WHOQOL–BREF scores with four variables including MAP, intelligence quotient (IQ), FBG, and age. The correlation analysis then showed that there was a weak linear correlation between the testosterone level and all five metabolic indices. Conclusions. Among the five metabolic indices, the risks of hypertension and hyperglycemia are correlated with the quality of life in male schizophrenics rather than those of obesity or hyperlipidemia.

• Publisher: Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc
• Subject: Adult / Age / Androgens / Blood Glucose - metabolism / Blood Pressure / Body mass / Body Mass Index / Body size / Cardiovascular disease / Care and treatment / Cholesterol / Cholesterol, HDL - blood / Cholesterol, LDL - blood / Complications and side effects / Correlation analysis / Cortisol / Cross-Sectional Studies / Demography / Diabetes / Diagnosis / Emotional Intelligence / Fasting / Glucose / Health aspects / Hormones / Humans / Hydrocortisone - blood / Hyperglycemia / Hyperglycemia - blood / Hyperglycemia - diagnosis / Hyperglycemia - physiopathology / Hyperglycemia - psychology / Hyperlipidemia / Hyperlipidemias - blood / Hyperlipidemias - diagnosis / Hyperlipidemias - physiopathology / Hyperlipidemias - psychology / Hypertension / Hypertension - blood / Hypertension - diagnosis / Hypertension - physiopathology / Hypertension - psychology / Immunoassay / Intelligence / Male / Men / Mental disorders / Mental health care / Metabolic disorders / Metabolic syndrome / Metabolic Syndrome - blood / Metabolic Syndrome - diagnosis / Metabolic Syndrome - physiopathology / Metabolic Syndrome - psychology / Metabolic syndrome X / Nutrition / Obesity / Obesity - blood / Obesity - diagnosis / Obesity - physiopathology / Obesity - psychology / Physiological aspects / Prevention / Psychopathology / Psychotropic drugs / Quality of life / Quality of Life - psychology / Quotients / Regression analysis / Regression models / Risk factors / Schizophrenia / Schizophrenia - blood / Schizophrenia - diagnosis / Schizophrenia - physiopathology / Schizophrenic Psychology / Schizophrenics / Testosterone / Testosterone - blood / Triglycerides / Triglycerides - blood / Waist Circumference