Asset Details
Do you wish to reserve the book?
The NLRP3 inflammasome: a therapeutic target of phytochemicals in treating atherosclerosis (a systematic review)
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The NLRP3 inflammasome: a therapeutic target of phytochemicals in treating atherosclerosis (a systematic review)
Do you wish to request the book?
The NLRP3 inflammasome: a therapeutic target of phytochemicals in treating atherosclerosis (a systematic review)
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The NLRP3 inflammasome: a therapeutic target of phytochemicals in treating atherosclerosis (a systematic review)
2025
Overview
Atherosclerosis (AS) is a chronic inflammatory disease characterized by the gradual accumulation of plaques in arterial walls, with its pathogenesis remaining incompletely understood. Recent studies have highlighted that development of AS is closely associated with the aberrant activation of the NLRP3 inflammasome in the arteries. Inhibition of the NLRP3 inflammasome by natural products and formulae derived from Chinese herbal medicines (CHMs) has been shown to alleviate AS-associated pathologies. However, therapies that effectively and safely target the NLRP3 inflammasome remain limited. This review aims to summarize the key discoveries from recent studies on the effects of these natural products and formulae on the NLRP3 inflammasome in the context of AS treatment. A comprehensive literature search was conducted on databases such as PubMed/MEDLINE up to January 2025, yielding 38 eligible studies. Our analysis indicates that certain therapies can effectively prevent arterial inflammation in animal models by targeting multiple pathways and mechanisms related to the NLRP3 inflammasome. This review summarizes the primary findings of these studies, focusing on the therapeutic effects and underlying mechanisms of action. Based on these insights, we propose future strategies to enhance the efficacy, specificity, and safety of existing natural products and formulae for AS treatment. Additionally, this study offers a perspective for future research that may enhance our understanding of the roles and the mechanisms of CHM-derived phytochemicals and formulae in regulating the NLRP3 inflammasome and treating AS.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Animals
/ Arteries
/ Atherosclerosis - drug therapy
/ Atherosclerosis - immunology
/ Atherosclerosis - metabolism
/ Drugs
/ Drugs, Chinese Herbal - therapeutic use
/ Humans
/ Inflammasomes - antagonists & inhibitors
/ Lipids
/ NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors
/ NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
/ NLRP3
/ Phytochemicals - pharmacology
/ Phytochemicals - therapeutic use
/ Proteins
/ Statins
