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Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
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Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
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Journal Article
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016
Overview
Adaptive immunity had been long thought of as an exclusive feature of animals. However, the discovery of the CRISPR-Cas defense system, present in almost half of prokaryotic genomes, proves otherwise. Because of the everlasting parasite-host arms race, CRISPR-Cas has rapidly evolved through horizontal transfer of complete loci or individual modules, resulting in extreme structural and functional diversity. CRISPR-Cas systems are divided into two distinct classes that each consist of three types and multiple subtypes. We discuss recent advances in CRISPR-Cas research that reveal elaborate molecular mechanisms and provide for a plausible scenario of CRISPR-Cas evolution. We also briefly describe the latest developments of a wide range of CRISPR-based applications.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ CRISPR-Associated Proteins - chemistry
/ CRISPR-Associated Proteins - genetics
/ CRISPR-Cas Systems - genetics
/ CRISPR-Cas Systems - physiology
/ DNA
/ Genetics
/ Genomes
/ Immunity
/ Interspersed Repetitive Sequences - immunology
/ Laboratorium voor Microbiologie
/ Loci
/ Proteins
/ Race
/ RNA, Guide, CRISPR-Cas Systems - metabolism
/ Roots
/ Structural Analysis (Linguistics)
/ Structural Analysis (Science)
/ VLAG
