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Cytokine profiles as novel diagnostic markers of Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in children

by Han, Xiu-cui , Tang, Yong-min , Zhang, Ting , Ye, Qing , Xu, Xiao-jun , Zhang, Wei-ying

in Anemia / Biomarkers - metabolism / Child / Child, Preschool / Children & youth / Critical care / Cytokines / Cytokines - metabolism / EBV-HLH / Epstein-Barr virus / Epstein-Barr Virus Infections - diagnosis / Female / Fever / Flow Cytometry / Gram-positive bacteria / Herpesvirus 4, Human / Humans / IFN-γ/Il-6 / Il-10/Il-6 / Infant / Inflammation / Interleukins - metabolism / Lymphatic diseases / Lymphohistiocytosis, Hemophagocytic - diagnosis / Lymphohistiocytosis, Hemophagocytic - virology / Male / Medical diagnosis / Medical prognosis / Pediatrics / Prospective Studies / Sensitivity and Specificity / Sepsis / Tumor Necrosis Factor-alpha - metabolism / Viral infections

2017

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Cytokine profiles as novel diagnostic markers of Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in children

by Han, Xiu-cui , Tang, Yong-min , Zhang, Ting , Ye, Qing , Xu, Xiao-jun , Zhang, Wei-ying

2017

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Cytokine profiles as novel diagnostic markers of Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in children

by Han, Xiu-cui , Tang, Yong-min , Zhang, Ting , Ye, Qing , Xu, Xiao-jun , Zhang, Wei-ying

2017

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Journal Article

Cytokine profiles as novel diagnostic markers of Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in children

Han, Xiu-cui,

Tang, Yong-min,

Zhang, Ting,

Ye, Qing,

Xu, Xiao-jun,

Zhang, Wei-ying

2017

Overview

The aim of this study was to identify specific laboratory indices to distinguish Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis (EBV-HLH) in children. In this prospective study, Th1/Th2 cytokines, including IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ, were analyzed in patients with EBV-HLH or sepsis at the onset of disease by flow cytometry. IL-10, IFN-γ, IL-10/IL-6, and IFN-γ/IL-6 were higher and IL-6 was lower in EBV-HLH patients compared to sepsis patient levels. When using the criteria of IL-10 >20.9 pg/mL, IFN-γ >17.9 pg/mL, IL-10/IL-6 >0.5 and IFN-γ/IL-6 >0.7, the sensitivity was 89.8%, 93.2%, 93.2%, and 91.5%, while the specificity was 89.8%, 100%, 94.9%, and 100%, respectively. After treatment of EBV-HLH patients, IL-6, IL-10, TNF-α, and IFN-γ were significantly reduced (IL-6: P<.001; IL-10: P<.001; TNF-α: P=.011; IFN-γ: P<.001). This study showed that IFN-γ, IL-10/IL-6, and IFN-γ/IL-6 are novel specific indicators for differential diagnosis of EBV-HLH. Additionally, IL-6, IL-10, TNF-α, and IFN-γ are useful indices for monitoring the effects of treatment on EBV-HLH. •IFN-γ, IL-10/IL-6 and IFN-γ/IL-6 are new, specific indicators for the differential diagnosis of EBV-HLH.•IL-6, IL-10, TNF-α, and IFN-γ are useful indices for the observation of a curative effect in EBV-HLH.

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Publisher

Elsevier Inc,Elsevier Limited

Subject

Anemia

/ Biomarkers - metabolism

/ Child