Asset Details
Do you wish to reserve the book?
Results of 20- versus 45-min post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Results of 20- versus 45-min post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia
Do you wish to request the book?
Results of 20- versus 45-min post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Results of 20- versus 45-min post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia
2016
Overview
Purpose
For patients, chemotherapy-induced alopecia (CIA) is one of the most distressing side effects of treatment. Scalp cooling can prevent or minimise CIA; the results may depend on the duration of cooling. Since a previous study on post-infusion cooling time in patients treated with docetaxel chemotherapy found no difference between 90 and 45 min, we investigated whether hair-preserving results could be maintained with a shorter post-infusion cooling time.
Methods
In this prospective, multi-centre randomised study, 134 patients who started treatment with docetaxel 75–100 mg/m
2
in a 3-weekly schedule were randomly assigned in a 1:1 ratio to a post-infusion cooling time of 45 or 20 min. The primary end point was the need for a wig or other head covering as assessed by the patient. A visual analogue scale (VAS) with a range from 0 (not tolerable) to 10 (very tolerable) was used to measure tolerance.
Results
Scalp cooling results were similar for 45- and 20-min post-infusion cooling times. Thirty-three out of 45 patients (73 %) treated with 20 min of post-infusion cooling did not need a form of head covering, compared with 41 out of 52 patients (79 %) treated with 45 min of post-infusion cooling (
p
= 0.5). The procedure was well tolerated (mean visual analogue score 8.3). Six patients stopped due to intolerance during the first treatment cycle.
Conclusions
A 20-min post-infusion cooling time is effective and tolerable for patients treated with scalp cooling to prevent docetaxel-induced alopecia.
Trial registration
Trialregister.nl Identifier, NTR 1856.
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
/ Aged
/ Alopecia
/ Alopecia - chemically induced
/ Alopecia - prevention & control
/ Antineoplastic Agents - adverse effects
/ Cancer
/ Drug-Related Side Effects and Adverse Reactions - prevention & control
/ Female
/ Hair
/ Humans
/ Hypothermia, Induced - methods
/ Induced
/ Male
/ Medicine
/ Nursing
/ Oncology
/ Outcome Assessment (Health Care)
/ Patients
/ Scalp
/ Time
