Asset Details
Do you wish to reserve the book?
Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo
Do you wish to request the book?
Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo
2010
Overview
Aim： To investigate the neuroprotective effects of morin on 1-methyt-4-phenylpyridinium ion （MPP＋）-induced apoptosis in neuronal dif- ferentiated PC12 cells as well as in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine （MPTP） mouse model of Parkinson disease （PD）. Methods： PC12 cells were challenged with MPP in the presence or absence of morin. Cell viability was determined using MTT assay. Cell apoptosis was measured using flow cytometry. Generation of reactive oxygen species （ROS） was assayed using fluorescence assay. In an MPTP mouse model of PD, behavioral deficits, striatal dopamine content, and number of dopaminergic neurons were measured. Results： MPP~ induced apoptosis and ROS formation in PC12 cells. Concomitant treatment with morin （5-50 IJmol/L） significantly attenuated the loss of cell viability and apoptosis when compared with MPP~ treatment alone. Morin also attenuated ROS formation induced by MPP . MPTP induced permanent behavioral deficits and nigrostriatal lesions in mice. When administered prior to MPTP, morin （20 to 100 mg/kg） attenuated behavioral deficits, dopaminergic neuronal death and striatal dopamine depletion in the MPTP mouse model. Conclusion： The findings suggest that morin has neuroprotective actions both in vitro and in vivo, and may provide a novel therapeutic agent for the treatment of PD and other neurodegenerative diseases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
/ Animals
/ Antiparkinson Agents - administration & dosage
/ Antiparkinson Agents - pharmacology
/ Biomedical and Life Sciences
/ Cell Survival - drug effects
/ Dose-Response Relationship, Drug
/ Flavonoids - administration & dosage
/ Male
/ Mice
/ MPP系统
/ Neuroprotective Agents - administration & dosage
/ Neuroprotective Agents - pharmacology
/ Original
/ Parkinsonian Disorders - drug therapy
/ Parkinsonian Disorders - physiopathology
/ PC12细胞
/ Rats
/ Reactive Oxygen Species - metabolism
/ Vaccine
/ 多巴胺能神经元
/ 小鼠模型
/ 帕金森病
/ 神经保护作用
