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Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response
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Journal Article
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response
2009
Overview
Basophils act as effector cells in immunoglobulin E–mediated hypersensitivity responses. Artis, Nakanishi and Medzhitov and their colleagues report that basophils present antigen and induce T helper type 2 responses to helminths, allergens and immunoglobulin E immune complexes.
T helper type 2 (T
H
2)-mediated immune responses are induced after infection with multicellular parasites and can be triggered by a variety of allergens. The mechanisms of induction and the antigen-presenting cells involved in the activation of T
H
2 responses remain poorly defined, and the innate immune sensing pathways activated by parasites and allergens are largely unknown. Basophils are required for the
in vivo
induction of T
H
2 responses by protease allergens. Here we show that basophils also function as antigen-presenting cells. We show that although dendritic cells were dispensable for allergen-induced activation of T
H
2 responses
in vitro
and
in vivo
, antigen presentation by basophils was necessary and sufficient for this. Thus, basophils function as antigen-presenting cells for T
H
2 differentiation in response to protease allergens.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Antigen-Presenting Cells - cytology
/ Antigen-Presenting Cells - immunology
/ Antigen-Presenting Cells - metabolism
/ Antigens, Helminth - immunology
/ Biomedical and Life Sciences
/ Bone Marrow Cells - cytology
/ Bone Marrow Cells - immunology
/ Bone Marrow Cells - metabolism
/ CD4-Positive T-Lymphocytes - cytology
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - metabolism
/ Cell Differentiation - immunology
/ Female
/ Histocompatibility Antigens Class II - genetics
/ Histocompatibility Antigens Class II - immunology
/ Male
/ Mice
/ Nuclear Proteins - immunology
/ Nuclear Proteins - metabolism
/ Reverse Transcriptase Polymerase Chain Reaction
/ T cells
