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PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
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PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
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PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
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Journal Article
PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
2013
Overview
Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that
EZH2
and other PRC2 members were highly expressed in SCLC. ChIP-seq for H3K27me3 suggested that genes with H3K27me3(+) in SCLC were extended not only to PRC2-target genes in ES cells but also to other target genes such as cellular adhesion-related genes. These H3K27me3(+) genes in SCLC were repressed significantly and introduction of the most repressed gene
JUB
into SCLC cell line lead to growth inhibition. Shorter overall survival of clinical SCLC cases correlated to repression of
JUB
alone, or a set of four genes including H3K27me3(+) genes. Treatment with EZH2 inhibitors, DZNep and GSK126, resulted in growth repression of SCLC cell lines. High PRC2 expression was suggested to contribute to gene repression in SCLC and may play a role in genesis of SCLC.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Chromatin Immunoprecipitation
/ Enhancer of Zeste Homolog 2 Protein
/ Fluorescent Antibody Technique
/ Genes
/ Humanities and Social Sciences
/ Humans
/ Jumonji Domain-Containing Histone Demethylases
/ LIM Domain Proteins - genetics
/ LIM Domain Proteins - metabolism
/ Lungs
/ Oligonucleotide Array Sequence Analysis
/ Polycomb Repressive Complex 2 - antagonists & inhibitors
/ Polycomb Repressive Complex 2 - genetics
/ Polycomb Repressive Complex 2 - metabolism
/ Real-Time Polymerase Chain Reaction
/ Reverse Transcriptase Polymerase Chain Reaction
/ Science
/ Small Cell Lung Carcinoma - genetics
/ Small Cell Lung Carcinoma - metabolism
