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The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease
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The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease
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Journal Article
The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease
2016
Overview
Globally breast cancer is the leading cause of cancer death among women. The breast consists of epithelium, stroma and a mucosal immune system that make up a complex microenvironment. Growing awareness of the role of microbes in the microenvironment recently has led to a series of findings important for human health. The microbiome has been implicated in cancer development and progression at a variety of body sites including stomach, colon, liver, lung and skin. In this study, we assessed breast tissue microbial signatures in intraoperatively obtained samples using 16S rDNA hypervariable tag sequencing. Our results indicate a distinct breast tissue microbiome that is different from the microbiota of breast skin tissue, breast skin swabs and buccal swabs. Furthermore, we identify distinct microbial communities in breast tissues from women with cancer as compared to women with benign breast disease. Malignancy correlated with enrichment in taxa of lower abundance including the genera
Fusobacterium, Atopobium, Gluconacetobacter, Hydrogenophaga
and
Lactobacillus
. This work confirms the existence of a distinct breast microbiome and differences between the breast tissue microbiome in benign and malignant disease. These data provide a foundation for future investigation on the role of the breast microbiome in breast carcinogenesis and breast cancer prevention.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/23
/ 38/47
/ Adult
/ Aged
/ Asepsis
/ Bacteria - isolation & purification
/ Benign
/ Breast Diseases - microbiology
/ Breast Neoplasms - microbiology
/ Breasts
/ Colon
/ Female
/ Humanities and Social Sciences
/ Humans
/ Liver
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Science
/ Skin
/ Stomach
/ Stroma
/ Tissues
