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Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects and tissue-specific enrichment of eQTLs
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Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects and tissue-specific enrichment of eQTLs
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Journal Article
Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects and tissue-specific enrichment of eQTLs
2016
Overview
We performed genome-wide meta-analysis of lipid traits on three samples of Mexican and Mexican American ancestry comprising 4,383 individuals and followed up significant and highly suggestive associations in three additional Hispanic samples comprising 7,876 individuals. Genome-wide significant signals were observed in or near
CELSR2
,
ZNF259/APOA5
,
KANK2/DOCK6
and
NCAN/MAU2
for total cholesterol,
LPL, ABCA1, ZNF259/APOA5
,
LIPC
and
CETP
for HDL cholesterol,
CELSR2, APOB
and
NCAN/MAU2
for LDL cholesterol and
GCKR
,
TRIB1
,
ZNF259/APOA5
and NCAN/
MAU2
for triglycerides. Linkage disequilibrium and conditional analyses indicate that signals observed at
ABCA1
and
LIPC
for HDL cholesterol and
NCAN/MAU2
for triglycerides are independent of previously reported lead SNP associations. Analyses of lead SNPs from the European Global Lipids Genetics Consortium (GLGC) dataset in our Hispanic samples show remarkable concordance of direction of effects as well as strong correlation in effect sizes. A meta-analysis of the European GLGC and our Hispanic datasets identified five novel regions reaching genome-wide significance: two for total cholesterol (
FN1
and
SAMM50
), two for HDL cholesterol (
LOC100996634
and
COPB1
) and one for LDL cholesterol (
LINC00324/CTC1/PFAS
). The top meta-analysis signals were found to be enriched for SNPs associated with gene expression in a tissue-specific fashion, suggesting an enrichment of tissue-specific function in lipid-associated loci.
Publisher
Nature Publishing Group UK,Nature Publishing Group
