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The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
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Journal Article
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
2004
Overview
Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Bacteria
/ Biomedical and Life Sciences
/ Extracellular Matrix - immunology
/ extracellular matrix proteins
/ Extracellular Matrix Proteins - genetics
/ Extracellular Matrix Proteins - immunology
/ Female
/ Gram-Negative Bacteria - immunology
/ Gram-Negative Bacteria - pathogenicity
/ Gram-Negative Bacterial Infections - immunology
/ Gram-Negative Bacterial Infections - microbiology
/ Gram-Positive Bacteria - immunology
/ Gram-Positive Bacteria - pathogenicity
/ Gram-Positive Bacterial Infections - immunology
/ Gram-Positive Bacterial Infections - microbiology
/ Humans
/ Lipopolysaccharides - immunology
/ Macrophages, Peritoneal - immunology
/ Macrophages, Peritoneal - microbiology
/ Male
/ Mice
/ mindin
