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The effect of short-chain fatty acids on human monocyte-derived dendritic cells
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The effect of short-chain fatty acids on human monocyte-derived dendritic cells
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Journal Article
The effect of short-chain fatty acids on human monocyte-derived dendritic cells
2015
Overview
The gut microbiota is essential for human health and plays an important role in the pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate and propionate, are end-products of microbial fermentation of macronutrients that distribute systemically via the blood. The aim of this study was to investigate the transcriptional response of immature and LPS-matured human monocyte-derived DC to SCFA. Our data revealed distinct effects exerted by each individual SCFA on gene expression in human monocyte-derived DC, especially in the mature ones. Acetate only exerted negligible effects, while both butyrate and propionate strongly modulated gene expression in both immature and mature human monocyte-derived DC. An Ingenuity pathway analysis based on the differentially expressed genes suggested that propionate and butyrate modulate leukocyte trafficking, as SCFA strongly reduced the release of several pro-inflammatory chemokines including CCL3, CCL4, CCL5, CXCL9, CXCL10 and CXCL11. Additionally, butyrate and propionate inhibited the expression of lipopolysaccharide (LPS)-induced cytokines such as IL-6 and IL-12p40 showing a strong anti-inflammatory effect. This work illustrates that bacterial metabolites far from the site of their production can differentially modulate the inflammatory response and generally provides new insights into host-microbiome interactions.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 13/31
/ 38
/ 38/61
/ 38/77
/ 38/90
/ 631/250
/ 631/80
/ 82
/ 82/80
/ Chemokines, CXC - metabolism
/ Dendritic Cells - drug effects
/ Dendritic Cells - metabolism
/ Fatty Acids, Volatile - metabolism
/ Gastrointestinal Microbiome - physiology
/ Gene Expression - drug effects
/ Humanities and Social Sciences
/ Humans
/ Interleukin-12 Subunit p40 - metabolism
/ Lipopolysaccharides - pharmacology
/ Science
