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Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model
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Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model
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Journal Article
Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model
2016
Overview
Controversy remains whether articular cartilage has an endogenous stem/progenitor cell population, since its poor healing capacity after injury can lead to diseases such as osteoarthritis. In the joint environment there are mesenchymal stem/progenitor cells (MSCs) in the synovial membrane and synovial fluid that can differentiate into cartilage, but it is still under debate if these cells contribute to cartilage repair
in vivo
. In this study, we isolated a Sca-1 positive, chondrogenesis capable population of mouse synovial MSCs from C57BL6 and MRL/MpJ “super-healer” strains. Intra-articular injection of Sca-1 + GFP + synovial cells from C57BL6 or MRL/MpJ into C57BL6 mice following cartilage injury led to increased cartilage repair by 4 weeks after injury. GFP expression was detected in the injury site at 2 weeks, but not 4 weeks after injury. These results suggest that synovial stem/progenitor cells, regardless of strain background, have beneficial effects when injected into an injured joint. MSCs derived from MRL/MpJ mice did not promote an increased repair capacity compared to MSCs derived from non-healing C57BL6 controls; however, MRL/MpJ MSCs were observed within the defect area at the time points examined, while C57BL6 MSCs were not.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 59
/ 59/57
/ 64
/ 64/60
/ Animals
/ Cartilage, Articular - diagnostic imaging
/ Cartilage, Articular - injuries
/ Cartilage, Articular - pathology
/ Green Fluorescent Proteins - genetics
/ Green Fluorescent Proteins - metabolism
/ Humanities and Social Sciences
/ Mesenchymal Stem Cell Transplantation
/ Mesenchymal Stromal Cells - cytology
/ Mesenchymal Stromal Cells - metabolism
/ Mice
/ Rodents
/ Science
/ Synovial Membrane - cytology
