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Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7
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Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7
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Journal Article
Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7
2017
Overview
Mature dendritic cells (DCs) home to secondary lymphoid organs through CC chemokine receptor 7 (CCR7). Exosomes derived from DCs (DC-exos) are reported to migrate to spleen and induce inflammation
in vivo
. In this study, we demonstrated that mature bone marrow DC-exos can activate immature DC and T cells
in vitro
. Then we intravenously injected DC-exos into C57BL/6 mice, observing that mature DC-exos accumulated more in spleen than immature DC-exos. These DC-exos in spleen could be uptaken by splenetic DCs and T cells and induce an inflammatory response. We further showed that the increased accumulation of mature DC-exos in spleen was regulated by CCR7, whose reduction led to a decrease of accumulation in spleen and attenuated inflammatory response in serum. These data provide us a new perspective to comprehensively understand exosomes, which might inherit some special functions from their parent cells and exert these functions
in vivo
.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/89
/ 14/19
/ Animals
/ Bone Marrow Cells - cytology
/ CD4-Positive T-Lymphocytes - cytology
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - metabolism
/ Dendritic Cells - metabolism
/ Exosomes
/ Humanities and Social Sciences
/ Mice
/ Organic Chemicals - chemistry
/ Receptors, CCR7 - antagonists & inhibitors
/ Receptors, CCR7 - metabolism
/ RNA, Small Interfering - metabolism
/ Rodents
/ Science
/ Spleen
