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Cellular prion protein is present in mitochondria of healthy mice
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Journal Article
Cellular prion protein is present in mitochondria of healthy mice
2017
Overview
Cellular prion protein (PrP
C
) is a mammalian glycoprotein which is usually found anchored to the plasma membrane via a glycophosphatidylinositol (GPI) anchor. PrP
C
misfolds to a pathogenic isoform PrP
Sc
, the causative agent of neurodegenerative prion diseases. The precise function of PrP
C
remains elusive but may depend upon its cellular localization. Here we show that PrP
C
is present in brain mitochondria from 6–12 week old wild-type and transgenic mice in the absence of disease. Mitochondrial PrP
C
was fully processed with mature N-linked glycans and did not require the GPI anchor for localization. Protease treatment of purified mitochondria suggested that mitochondrial PrP
C
exists as a transmembrane isoform with the C-terminus facing the mitochondrial matrix and the N-terminus facing the intermembrane space. Taken together, our data suggest that PrP
C
can be found in mitochondria in the absence of disease, old age, mutation, or overexpression and that PrP
C
may affect mitochondrial function.
Publisher
Nature Publishing Group UK,Nature Publishing Group
