Asset Details
Do you wish to reserve the book?
Anti-tumor effects of DNA vaccine targeting human fibroblast activation protein α by producing specific immune responses and altering tumor microenvironment in the 4T1 murine breast cancer model
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Anti-tumor effects of DNA vaccine targeting human fibroblast activation protein α by producing specific immune responses and altering tumor microenvironment in the 4T1 murine breast cancer model
Do you wish to request the book?
Anti-tumor effects of DNA vaccine targeting human fibroblast activation protein α by producing specific immune responses and altering tumor microenvironment in the 4T1 murine breast cancer model
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Anti-tumor effects of DNA vaccine targeting human fibroblast activation protein α by producing specific immune responses and altering tumor microenvironment in the 4T1 murine breast cancer model
2016
Overview
Fibroblast activation protein α (FAPα) is a tumor stromal antigen overexpressed by cancer-associated fibroblasts (CAFs). CAFs are genetically more stable compared with the tumor cells and immunosuppressive components of the tumor microenvironment, rendering them excellent targets for cancer immunotherapy. DNA vaccines are widely applied due to their safety. To specifically destroy CAFs, we constructed and examined the immunogenicity and anti-tumor immune mechanism of a DNA vaccine expressing human FAPα. This vaccine successfully reduced 4T1 tumor growth through producing FAPα-specific cytotoxic T lymphocyte responses which could kill CAFs, and the decrease in FAPα-expressing CAFs resulted in markedly attenuated expression of collagen I and other stromal factors that benefit the tumor progression. Based on these results, a DNA vaccine targeting human FAPα may be an attractive and effective cancer immunotherapy strategy.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Antigens
/ Cancer Vaccines - immunology
/ Cancer Vaccines - pharmacology
/ Collagen Type I - immunology
/ Collagen Type I - metabolism
/ Female
/ Humans
/ Mammary Neoplasms, Experimental - drug therapy
/ Mammary Neoplasms, Experimental - immunology
/ Mammary Neoplasms, Experimental - pathology
/ Medicine
/ Membrane Proteins - genetics
/ Membrane Proteins - immunology
/ Membrane Proteins - metabolism
/ Oncology
/ Original
/ Plasmids
/ Proteins
/ Serine Endopeptidases - genetics
/ Serine Endopeptidases - immunology
/ Serine Endopeptidases - metabolism
/ T-Lymphocytes, Cytotoxic - drug effects
/ T-Lymphocytes, Cytotoxic - immunology
/ Tumor Microenvironment - drug effects
/ Tumor Microenvironment - immunology
/ Vaccines
