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REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

by Stahl, Neil , Baum, Alina , Norton, Thomas , Sivapalasingam, Sumathi , Kampman, Wendy , Kohli, Anita , Sachdeva, Yessica , Im, Joseph , Hamilton, Jennifer D , DiCioccio, Thomas , Davis, John D , Weinreich, David M , Gao, Haitao , Hosain, Romana , Lipsich, Leah , Ali, Shazia , Kyratsous, Christos A , Rofail, Diana , Hooper, Andrea T , Graber, Ximena , Bhore, Rafia , Mahmood, Adnan , Kim, Yunji , Pan, Cynthia , Musser, Bret J , Herman, Gary , Turner, Kenneth C , Kowal, Bari , Yancopoulos, George D , Cook, Amanda , Braunstein, Ned , Soo, Yuhwen , Perry, Christina

in Adult / Adverse events / Antibodies / Antibodies, Monoclonal, Humanized - adverse effects / Antibodies, Monoclonal, Humanized - therapeutic use / Antibodies, Neutralizing - adverse effects / Antibodies, Neutralizing - therapeutic use / Antiviral drugs / Clinical medicine / Coronaviridae / Coronaviruses / COVID-19 / COVID-19 - diagnosis / COVID-19 - drug therapy / COVID-19 - virology / Double-Blind Method / Drug Combinations / Female / Humans / Hypersensitivity / Hypotheses / Hypothesis testing / Immune response / Immunologic Factors - adverse effects / Immunologic Factors - therapeutic use / Least-Squares Analysis / Male / Middle Aged / Monoclonal antibodies / Original / Outpatients / Pharmacokinetics / Placebos / Proteins / Resistant mutant / Reverse Transcriptase Polymerase Chain Reaction / SARS-CoV-2 - genetics / SARS-CoV-2 - isolation & purification / Severe acute respiratory syndrome coronavirus 2 / Spike protein / Statistical analysis / Viral Load - drug effects

2021

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REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

2021

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REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

2021

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Journal Article

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

Stahl, Neil,

Baum, Alina,

Norton, Thomas,

Sivapalasingam, Sumathi,

Kampman, Wendy,

Kohli, Anita,

Sachdeva, Yessica,

Im, Joseph,

Hamilton, Jennifer D,

DiCioccio, Thomas,

Davis, John D,

Weinreich, David M,

Gao, Haitao,

Hosain, Romana,

Lipsich, Leah,

Ali, Shazia,

Kyratsous, Christos A,

Rofail, Diana,

Hooper, Andrea T,

Graber, Ximena,

Bhore, Rafia,

Mahmood, Adnan,

Kim, Yunji,

Pan, Cynthia,

Musser, Bret J,

Herman, Gary,

Turner, Kenneth C,

Kowal, Bari,

Yancopoulos, George D,

Cook, Amanda,

Braunstein, Ned,

Soo, Yuhwen,

Perry, Christina

2021

Overview

An anti–SARS-CoV-2 antibody cocktail was given to patients within 3 days after PCR confirmation of Covid-19. In patients who were antibody-negative at baseline, treatment was associated with rapid viral clearance and potentially with a less frequent need for medical attention. The effect was less marked among patients who were antibody-positive at baseline.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Adverse events

/ Antibodies

/ Antibodies, Monoclonal, Humanized - adverse effects

/ Antibodies, Monoclonal, Humanized - therapeutic use

/ Antibodies, Neutralizing - adverse effects

/ Antibodies, Neutralizing - therapeutic use