Asset Details
Do you wish to reserve the book?
Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women
Do you wish to request the book?
Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women
2021
Overview
Aging women experience hormonal changes, such as decreased estrogen and increased circulating androgen, due to natural or surgical menopause. These hormonal changes make postmenopausal women vulnerable to body composition changes, muscle loss, and abdominal obesity; with a sedentary lifestyle, these changes affect overall energy expenditure and basal metabolic rate. In addition, fat redistribution due to hormonal changes leads to changes in body shape. In particular, increased bone marrow-derived adipocytes due to estrogen loss contribute to increased visceral fat in postmenopausal women. Enhanced visceral fat lipolysis by adipose tissue lipoprotein lipase triggers the production of excessive free fatty acids, causing insulin resistance and metabolic diseases. Because genes involved in β-oxidation are downregulated by estradiol loss, excess free fatty acids produced by lipolysis of visceral fat cannot be used appropriately as an energy source through β-oxidation. Moreover, aged women show increased adipogenesis due to upregulated expression of genes related to fat accumulation. As a result, the catabolism of ATP production associated with β-oxidation decreases, and metabolism associated with lipid synthesis increases. This review describes the changes in energy metabolism and lipid metabolic abnormalities that are the background of weight gain in postmenopausal women.
Publisher
MDPI AG,MDPI
Subject
/ Aged
/ Aging
/ Body fat
/ Energy
/ Fatty Acids, Nonesterified - metabolism
/ Female
/ Females
/ Humans
/ Intra-Abdominal Fat - metabolism
/ Lipid Metabolism Disorders - metabolism
/ Lipids
/ Lipoprotein Lipase - metabolism
/ Muscle, Skeletal - metabolism
/ muscles
/ obesity
/ Obesity, Abdominal - metabolism
/ Review
