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Unravelling cancer stem cell potential
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Journal Article
Unravelling cancer stem cell potential
2013
Overview
What can we learn about cancer stem cells and tumour tissue hierarchy from what we know about stem cells? Read this Opinion article to find out how our knowledge of normal stem cells applies to cancer stem cells in solid tumours.
The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which reside at the top of the cellular hierarchy of these tissues. Functional assays, such as
in vitro
clonogenic assays, transplantation and
in vivo
lineage tracing, have been used to assess the renewing and differentiation potential of normal SCs. Similar strategies have suggested that solid tumours may also be hierarchically organized and contain cancer SCs (CSCs) that sustain tumour growth and relapse after therapy. In this Opinion article, we discuss the different parallels that can be drawn between adult SCs and CSCs in solid tumours.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult Stem Cells - physiology
/ Animals
/ Cancer
/ Humans
/ Mice
/ Neoplasms, Experimental - pathology
/ Neoplastic Stem Cells - cytology
/ Neoplastic Stem Cells - drug effects
/ Neoplastic Stem Cells - physiology
/ Neoplastic Stem Cells - radiation effects
/ Neoplastic Stem Cells - transplantation
/ Tumors
