Journal Article

Genome-wide association study reveals two new risk loci for bipolar disorder

Polonikov, Alexey, Meier, Sandra, Strohmaier, Jana, Pantelejeva, Galina, Abramova, Lilia I., Kogevinas, Manolis, Witt, Stephanie H., Breuer, René, Kammerer-Ciernioch, Jutta, Montgomery, Grant W., Rivas, Fabio, Vedder, Helmut, Medland, Sarah E., Treutlein, Jens, Tiganov, Alexander S., Herms, Stefan, Mattheisen, Manuel, Wright, Adam, Hauser, Joanna, Szeszenia-Dabrowska, Neonila, Propping, Peter, Khusnutdinova, Elza, Degenhardt, Franziska, McKay, James D., Alda, Martin, Gordon, Scott D., Hoffmann, Per, Schofield, Peter R., Martin, Nicholas G., Bauer, Michael, Mayoral, Fermin, Turecki, Gustavo, Forstner, Andreas J., Laprise, Catherine, Grigoroiu-Serbanescu, Maria, Mühleisen, Thomas W., Krasnow, Valery, Grof, Paul, Maier, Wolfgang, Reif, Andreas, Moebus, Susanne, Becker, Tim, Schwarz, Markus, Lissowska, Jolanta, Chuchalin, Alexander, Rietschel, Marcella, Müller-Myhsok, Bertram, Priebe, Lutz, Lacour, André, Rouleau, Guy A., Pfennig, Andrea, Czerski, Piotr M., Cichon, Sven, Lucae, Susanne, Schumacher, Johannes, Brennan, Paul, Mitchell, Philip B., Fullerton, Janice M., Babadjanova, Gulja, Leber, Markus, Nöthen,

2014

Overview

Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3 , ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD. Bipolar disorder (BD) is a severe mood disorder, which has been shown to have a large genetic component. Here the authors identify two previously unreported BD risk loci and provide further insights into the biological mechanisms underlying BD development.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 45/43 / 45/47 / 45/77 / 631/208/205/2138 / 692/420/2489/144 / 692/699/476/1333 / Adenylyl Cyclases - genetics / Bipolar Disorder - genetics / Female / Genetic Predisposition to Disease - genetics / Genetic variance / Genome-Wide Association Study - methods / Humanities and Social Sciences / Humans / Male / Mental disorders / multidisciplinary / Polymorphism, Single Nucleotide - genetics / Science / Science (multidisciplinary)