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A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End‐Stage Renal Disease Undergoing Dialysis
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A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End‐Stage Renal Disease Undergoing Dialysis
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A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End‐Stage Renal Disease Undergoing Dialysis
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Journal Article
A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End‐Stage Renal Disease Undergoing Dialysis
2025
Overview
Introduction End‐stage renal disease (ESRD) is a severe condition that necessitates dialysis. Dialysis treatments, including hemodialysis and peritoneal dialysis, can affect various organs, including the brain, leading to potential cognitive decline. This study investigates the neurological effects and brain network reorganization in ESRD patients undergoing different dialysis methods. Methods A total of 120 ESRD patients were randomly divided into two groups: 60 patients undergoing hemodialysis and 60 undergoing peritoneal dialysis. Patients were followed for 1 year. Neuropsychological scales assessed cognitive function, and MRI scans were used to analyze brain structure and functional network dynamics before and after dialysis. Laboratory indicators and clinical outcomes were also recorded. Results Both dialysis methods improved renal function, but peritoneal dialysis showed more favorable effects on cognitive function, with higher MMSE and MOCA scores. MRI analysis revealed better functional brain network efficiency in the peritoneal dialysis group. No significant differences were observed in the incidence of complications between the two groups. Conclusion Although hemodialysis showed better renal function outcomes, peritoneal dialysis was associated with better cognitive performance and brain network reorganization. Both methods were safe, but peritoneal dialysis may offer neuroprotective benefits over hemodialysis in ESRD patients. Trial Registration National Health Insurance Medical Research Registration and Filing Information System: MR‐46‐22‐012452 Hemodialysis outperforms peritoneal dialysis in renal clearance and enhances brain default mode network activity, suggesting dual benefits of renal function improvement and neuroprotection.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
/ Aged
/ Anxiety
/ Chloride
/ Diabetes
/ Female
/ Females
/ Gender
/ Humans
/ Kidney Failure, Chronic - diagnostic imaging
/ Kidney Failure, Chronic - physiopathology
/ Kidney Failure, Chronic - therapy
/ Male
/ Males
/ Memory
/ Nerve Net - diagnostic imaging
/ Original
/ Peritoneal Dialysis - adverse effects
/ Peritoneal Dialysis - methods
